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The protective effects of ginsenoside Rg1 against hypertension target-organ damage in spontaneously hypertensive rats
BACKGROUND: Although a number of medicines are available for the management of hypertension, the organ damage induced by hypertension is not resolved. The aim of this study was to investigate the protection of ginsenoside Rg1 (Rg1) against vascular remodeling and organ damage in spontaneously hypert...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3453499/ https://www.ncbi.nlm.nih.gov/pubmed/22533478 http://dx.doi.org/10.1186/1472-6882-12-53 |
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author | Chen, Hui Yin, Jun Deng, Yanpin Yang, Min Xu, Lingling Teng, Fukang Li, Defang Cheng, Yufan Liu, Sha Wang, Dong Zhang, Tingting Wu, Wanying Liu, Xuan Guan, Shuhong Jiang, Baohong Guo, Dean |
author_facet | Chen, Hui Yin, Jun Deng, Yanpin Yang, Min Xu, Lingling Teng, Fukang Li, Defang Cheng, Yufan Liu, Sha Wang, Dong Zhang, Tingting Wu, Wanying Liu, Xuan Guan, Shuhong Jiang, Baohong Guo, Dean |
author_sort | Chen, Hui |
collection | PubMed |
description | BACKGROUND: Although a number of medicines are available for the management of hypertension, the organ damage induced by hypertension is not resolved. The aim of this study was to investigate the protection of ginsenoside Rg1 (Rg1) against vascular remodeling and organ damage in spontaneously hypertensive rats (SHR). METHODS: Male SHR were treated with 5, 10 or 20 mg/kg Rg1 through intraperitoneal injection per day for 1 month. SHR or Wistar-Kyoto rats (WKY) receiving vehicle (saline) was used as control. Blood pressure detection and pathological stain, transmission electron microscope, immunohistochemical assay were used to elucidate the protection of Rg1. RESULTS: Blood pressures were not different between control SHR rats and Rg1 treated SHR rats, but Rg1 improved the aortic outward remodeling by lowering the lumen diameter and reducing the media thickness according the histopathological and ultrastructural detections. Rg1 also protected the retinal vessels against inward remodeling detected by immunohistochemical assay. Furthermore, Rg1 attenuated the target heart and kidney damage with improvement on cardiac and glomerular structure. CONCLUSIONS: These results suggested that Rg1 held beneficial effects on vascular structure and further protected against the organ-damage induced by hypertension. These findings also paved a novel and promising approach to the treatment of hypertensive complications. |
format | Online Article Text |
id | pubmed-3453499 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-34534992012-09-25 The protective effects of ginsenoside Rg1 against hypertension target-organ damage in spontaneously hypertensive rats Chen, Hui Yin, Jun Deng, Yanpin Yang, Min Xu, Lingling Teng, Fukang Li, Defang Cheng, Yufan Liu, Sha Wang, Dong Zhang, Tingting Wu, Wanying Liu, Xuan Guan, Shuhong Jiang, Baohong Guo, Dean BMC Complement Altern Med Research Article BACKGROUND: Although a number of medicines are available for the management of hypertension, the organ damage induced by hypertension is not resolved. The aim of this study was to investigate the protection of ginsenoside Rg1 (Rg1) against vascular remodeling and organ damage in spontaneously hypertensive rats (SHR). METHODS: Male SHR were treated with 5, 10 or 20 mg/kg Rg1 through intraperitoneal injection per day for 1 month. SHR or Wistar-Kyoto rats (WKY) receiving vehicle (saline) was used as control. Blood pressure detection and pathological stain, transmission electron microscope, immunohistochemical assay were used to elucidate the protection of Rg1. RESULTS: Blood pressures were not different between control SHR rats and Rg1 treated SHR rats, but Rg1 improved the aortic outward remodeling by lowering the lumen diameter and reducing the media thickness according the histopathological and ultrastructural detections. Rg1 also protected the retinal vessels against inward remodeling detected by immunohistochemical assay. Furthermore, Rg1 attenuated the target heart and kidney damage with improvement on cardiac and glomerular structure. CONCLUSIONS: These results suggested that Rg1 held beneficial effects on vascular structure and further protected against the organ-damage induced by hypertension. These findings also paved a novel and promising approach to the treatment of hypertensive complications. BioMed Central 2012-04-25 /pmc/articles/PMC3453499/ /pubmed/22533478 http://dx.doi.org/10.1186/1472-6882-12-53 Text en Copyright ©2012 Chen et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Chen, Hui Yin, Jun Deng, Yanpin Yang, Min Xu, Lingling Teng, Fukang Li, Defang Cheng, Yufan Liu, Sha Wang, Dong Zhang, Tingting Wu, Wanying Liu, Xuan Guan, Shuhong Jiang, Baohong Guo, Dean The protective effects of ginsenoside Rg1 against hypertension target-organ damage in spontaneously hypertensive rats |
title | The protective effects of ginsenoside Rg1 against hypertension target-organ damage in spontaneously hypertensive rats |
title_full | The protective effects of ginsenoside Rg1 against hypertension target-organ damage in spontaneously hypertensive rats |
title_fullStr | The protective effects of ginsenoside Rg1 against hypertension target-organ damage in spontaneously hypertensive rats |
title_full_unstemmed | The protective effects of ginsenoside Rg1 against hypertension target-organ damage in spontaneously hypertensive rats |
title_short | The protective effects of ginsenoside Rg1 against hypertension target-organ damage in spontaneously hypertensive rats |
title_sort | protective effects of ginsenoside rg1 against hypertension target-organ damage in spontaneously hypertensive rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3453499/ https://www.ncbi.nlm.nih.gov/pubmed/22533478 http://dx.doi.org/10.1186/1472-6882-12-53 |
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