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Effect of zinc supplementation on growth Hormone Insulin growth factor axis in short Egyptian children with zinc deficiency

BACKGROUND: The relationship between zinc (Zn) and growth hormone-insulin growth factor (GH-IGF) system and how Zn therapy stimulates growth in children has not been clearly defined in humans. Thus, we aimed to assess GH-IGF axis in short children with Zn deficiency and to investigate the effect of...

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Autores principales: Hamza, Rasha T, Hamed, Amira I, Sallam, Mahmoud T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3453500/
https://www.ncbi.nlm.nih.gov/pubmed/22625223
http://dx.doi.org/10.1186/1824-7288-38-21
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author Hamza, Rasha T
Hamed, Amira I
Sallam, Mahmoud T
author_facet Hamza, Rasha T
Hamed, Amira I
Sallam, Mahmoud T
author_sort Hamza, Rasha T
collection PubMed
description BACKGROUND: The relationship between zinc (Zn) and growth hormone-insulin growth factor (GH-IGF) system and how Zn therapy stimulates growth in children has not been clearly defined in humans. Thus, we aimed to assess GH-IGF axis in short children with Zn deficiency and to investigate the effect of Zn supplementation on these parameters. METHODS: Fifty pre-pubertal Egyptian children with short stature and Zn deficiency were compared to 50 age-, sex-, and pubertal stage- matched controls. All subjects were subjected to history, auxological assessment and measurement of serum Zn, IGF-1, insulin growth factor binding protein-3 (IGFBP-3); and basal and stimulated GH before and 3 months after Zn supplementation (50 mg/day). RESULTS: After 3 months of Zn supplementation in Zn-deficient patients, there were significant increases in height standard deviation score (SDS, P = 0.033), serum Zn (P < 0.001), IGF-1 (P < 0.01), IGF-1 standard deviation score (SDS,P < 0.01) and IGFBP-3 (P = 0.042). Zn rose in all patients but reached normal ranges in 64 %, IGF-1 levels rose in 60 % but reached normal ranges in 40 % and IGFBP-3 levels rose in 40 % but reached reference ranges in 22 %. Growth velocity (GV) SDS did not differ between cases and controls (p = 0.15) but was higher in GH-deficient patients than non-deficient ones, both having Zn deficiency (p = 0.03). CONCLUSION: Serum IGF-1 and IGFBP-3 levels were low in short children with Zn deficiency, and increased after Zn supplementation for 3 months but their levels were still lower than the normal reference ranges in most children; therefore, Zn supplementation may be necessary for longer periods.
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spelling pubmed-34535002012-09-25 Effect of zinc supplementation on growth Hormone Insulin growth factor axis in short Egyptian children with zinc deficiency Hamza, Rasha T Hamed, Amira I Sallam, Mahmoud T Ital J Pediatr Research BACKGROUND: The relationship between zinc (Zn) and growth hormone-insulin growth factor (GH-IGF) system and how Zn therapy stimulates growth in children has not been clearly defined in humans. Thus, we aimed to assess GH-IGF axis in short children with Zn deficiency and to investigate the effect of Zn supplementation on these parameters. METHODS: Fifty pre-pubertal Egyptian children with short stature and Zn deficiency were compared to 50 age-, sex-, and pubertal stage- matched controls. All subjects were subjected to history, auxological assessment and measurement of serum Zn, IGF-1, insulin growth factor binding protein-3 (IGFBP-3); and basal and stimulated GH before and 3 months after Zn supplementation (50 mg/day). RESULTS: After 3 months of Zn supplementation in Zn-deficient patients, there were significant increases in height standard deviation score (SDS, P = 0.033), serum Zn (P < 0.001), IGF-1 (P < 0.01), IGF-1 standard deviation score (SDS,P < 0.01) and IGFBP-3 (P = 0.042). Zn rose in all patients but reached normal ranges in 64 %, IGF-1 levels rose in 60 % but reached normal ranges in 40 % and IGFBP-3 levels rose in 40 % but reached reference ranges in 22 %. Growth velocity (GV) SDS did not differ between cases and controls (p = 0.15) but was higher in GH-deficient patients than non-deficient ones, both having Zn deficiency (p = 0.03). CONCLUSION: Serum IGF-1 and IGFBP-3 levels were low in short children with Zn deficiency, and increased after Zn supplementation for 3 months but their levels were still lower than the normal reference ranges in most children; therefore, Zn supplementation may be necessary for longer periods. BioMed Central 2012-05-24 /pmc/articles/PMC3453500/ /pubmed/22625223 http://dx.doi.org/10.1186/1824-7288-38-21 Text en Copyright ©2012 Hamza et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Hamza, Rasha T
Hamed, Amira I
Sallam, Mahmoud T
Effect of zinc supplementation on growth Hormone Insulin growth factor axis in short Egyptian children with zinc deficiency
title Effect of zinc supplementation on growth Hormone Insulin growth factor axis in short Egyptian children with zinc deficiency
title_full Effect of zinc supplementation on growth Hormone Insulin growth factor axis in short Egyptian children with zinc deficiency
title_fullStr Effect of zinc supplementation on growth Hormone Insulin growth factor axis in short Egyptian children with zinc deficiency
title_full_unstemmed Effect of zinc supplementation on growth Hormone Insulin growth factor axis in short Egyptian children with zinc deficiency
title_short Effect of zinc supplementation on growth Hormone Insulin growth factor axis in short Egyptian children with zinc deficiency
title_sort effect of zinc supplementation on growth hormone insulin growth factor axis in short egyptian children with zinc deficiency
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3453500/
https://www.ncbi.nlm.nih.gov/pubmed/22625223
http://dx.doi.org/10.1186/1824-7288-38-21
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