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Effect of zinc supplementation on growth Hormone Insulin growth factor axis in short Egyptian children with zinc deficiency
BACKGROUND: The relationship between zinc (Zn) and growth hormone-insulin growth factor (GH-IGF) system and how Zn therapy stimulates growth in children has not been clearly defined in humans. Thus, we aimed to assess GH-IGF axis in short children with Zn deficiency and to investigate the effect of...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3453500/ https://www.ncbi.nlm.nih.gov/pubmed/22625223 http://dx.doi.org/10.1186/1824-7288-38-21 |
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author | Hamza, Rasha T Hamed, Amira I Sallam, Mahmoud T |
author_facet | Hamza, Rasha T Hamed, Amira I Sallam, Mahmoud T |
author_sort | Hamza, Rasha T |
collection | PubMed |
description | BACKGROUND: The relationship between zinc (Zn) and growth hormone-insulin growth factor (GH-IGF) system and how Zn therapy stimulates growth in children has not been clearly defined in humans. Thus, we aimed to assess GH-IGF axis in short children with Zn deficiency and to investigate the effect of Zn supplementation on these parameters. METHODS: Fifty pre-pubertal Egyptian children with short stature and Zn deficiency were compared to 50 age-, sex-, and pubertal stage- matched controls. All subjects were subjected to history, auxological assessment and measurement of serum Zn, IGF-1, insulin growth factor binding protein-3 (IGFBP-3); and basal and stimulated GH before and 3 months after Zn supplementation (50 mg/day). RESULTS: After 3 months of Zn supplementation in Zn-deficient patients, there were significant increases in height standard deviation score (SDS, P = 0.033), serum Zn (P < 0.001), IGF-1 (P < 0.01), IGF-1 standard deviation score (SDS,P < 0.01) and IGFBP-3 (P = 0.042). Zn rose in all patients but reached normal ranges in 64 %, IGF-1 levels rose in 60 % but reached normal ranges in 40 % and IGFBP-3 levels rose in 40 % but reached reference ranges in 22 %. Growth velocity (GV) SDS did not differ between cases and controls (p = 0.15) but was higher in GH-deficient patients than non-deficient ones, both having Zn deficiency (p = 0.03). CONCLUSION: Serum IGF-1 and IGFBP-3 levels were low in short children with Zn deficiency, and increased after Zn supplementation for 3 months but their levels were still lower than the normal reference ranges in most children; therefore, Zn supplementation may be necessary for longer periods. |
format | Online Article Text |
id | pubmed-3453500 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-34535002012-09-25 Effect of zinc supplementation on growth Hormone Insulin growth factor axis in short Egyptian children with zinc deficiency Hamza, Rasha T Hamed, Amira I Sallam, Mahmoud T Ital J Pediatr Research BACKGROUND: The relationship between zinc (Zn) and growth hormone-insulin growth factor (GH-IGF) system and how Zn therapy stimulates growth in children has not been clearly defined in humans. Thus, we aimed to assess GH-IGF axis in short children with Zn deficiency and to investigate the effect of Zn supplementation on these parameters. METHODS: Fifty pre-pubertal Egyptian children with short stature and Zn deficiency were compared to 50 age-, sex-, and pubertal stage- matched controls. All subjects were subjected to history, auxological assessment and measurement of serum Zn, IGF-1, insulin growth factor binding protein-3 (IGFBP-3); and basal and stimulated GH before and 3 months after Zn supplementation (50 mg/day). RESULTS: After 3 months of Zn supplementation in Zn-deficient patients, there were significant increases in height standard deviation score (SDS, P = 0.033), serum Zn (P < 0.001), IGF-1 (P < 0.01), IGF-1 standard deviation score (SDS,P < 0.01) and IGFBP-3 (P = 0.042). Zn rose in all patients but reached normal ranges in 64 %, IGF-1 levels rose in 60 % but reached normal ranges in 40 % and IGFBP-3 levels rose in 40 % but reached reference ranges in 22 %. Growth velocity (GV) SDS did not differ between cases and controls (p = 0.15) but was higher in GH-deficient patients than non-deficient ones, both having Zn deficiency (p = 0.03). CONCLUSION: Serum IGF-1 and IGFBP-3 levels were low in short children with Zn deficiency, and increased after Zn supplementation for 3 months but their levels were still lower than the normal reference ranges in most children; therefore, Zn supplementation may be necessary for longer periods. BioMed Central 2012-05-24 /pmc/articles/PMC3453500/ /pubmed/22625223 http://dx.doi.org/10.1186/1824-7288-38-21 Text en Copyright ©2012 Hamza et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Hamza, Rasha T Hamed, Amira I Sallam, Mahmoud T Effect of zinc supplementation on growth Hormone Insulin growth factor axis in short Egyptian children with zinc deficiency |
title | Effect of zinc supplementation on growth Hormone Insulin growth factor axis in short Egyptian children with zinc deficiency |
title_full | Effect of zinc supplementation on growth Hormone Insulin growth factor axis in short Egyptian children with zinc deficiency |
title_fullStr | Effect of zinc supplementation on growth Hormone Insulin growth factor axis in short Egyptian children with zinc deficiency |
title_full_unstemmed | Effect of zinc supplementation on growth Hormone Insulin growth factor axis in short Egyptian children with zinc deficiency |
title_short | Effect of zinc supplementation on growth Hormone Insulin growth factor axis in short Egyptian children with zinc deficiency |
title_sort | effect of zinc supplementation on growth hormone insulin growth factor axis in short egyptian children with zinc deficiency |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3453500/ https://www.ncbi.nlm.nih.gov/pubmed/22625223 http://dx.doi.org/10.1186/1824-7288-38-21 |
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