Human P301L-Mutant Tau Expression in Mouse Entorhinal-Hippocampal Network Causes Tau Aggregation and Presynaptic Pathology but No Cognitive Deficits

Accumulation of hyperphosphorylated tau in the entorhinal cortex (EC) is one of the earliest pathological hallmarks in patients with Alzheimer’s disease (AD). It can occur before significant Aβ deposition and appears to “spread” into anatomically connected brain regions. To determine whether this ea...

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Detalles Bibliográficos
Autores principales: Harris, Julie A., Koyama, Akihiko, Maeda, Sumihiro, Ho, Kaitlyn, Devidze, Nino, Dubal, Dena B., Yu, Gui-Qiu, Masliah, Eliezer, Mucke, Lennart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3454317/
https://www.ncbi.nlm.nih.gov/pubmed/23029293
http://dx.doi.org/10.1371/journal.pone.0045881

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3454317/
https://www.ncbi.nlm.nih.gov/pubmed/23029293
http://dx.doi.org/10.1371/journal.pone.0045881

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