11,12-EET Stimulates the Association of BK Channel α and β(1) Subunits in Mitochondria to Induce Pulmonary Vasoconstriction

In the systemic circulation, 11,12-epoxyeicosatrienoic acid (11,12-EET) elicits nitric oxide (NO)- and prostacyclin-independent vascular relaxation, partially through the activation of large conductance Ca(2+)-activated potassium (BK) channels. However, in the lung 11,12-EET contributes to hypoxia-i...

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Detalles Bibliográficos
Autores principales: Loot, Annemarieke E., Moneke, Isabelle, Keserü, Benjamin, Oelze, Matthias, Syzonenko, Tetyana, Daiber, Andreas, Fleming, Ingrid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3454360/
https://www.ncbi.nlm.nih.gov/pubmed/23029390
http://dx.doi.org/10.1371/journal.pone.0046065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3454360/
https://www.ncbi.nlm.nih.gov/pubmed/23029390
http://dx.doi.org/10.1371/journal.pone.0046065

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