Functional Redundancy of Class I Phosphoinositide 3-Kinase (PI3K) Isoforms in Signaling Growth Factor-Mediated Human Neutrophil Survival

We have investigated the contribution of individual phosphoinositide 3-kinase (PI3K) Class I isoforms to the regulation of neutrophil survival using (i) a panel of commercially available small molecule isoform-selective PI3K Class I inhibitors, (ii) novel inhibitors, which target single or multiple...

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Detalles Bibliográficos
Autores principales: Juss, Jatinder K., Hayhoe, Richard P., Owen, Charles E., Bruce, Ian, Walmsley, Sarah R., Cowburn, Andrew S., Kulkarni, Suhasini, Boyle, Keith B., Stephens, Len, Hawkins, Phillip T., Chilvers, Edwin R., Condliffe, Alison M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3454369/
https://www.ncbi.nlm.nih.gov/pubmed/23029326
http://dx.doi.org/10.1371/journal.pone.0045933

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