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In Vitro and In Vivo Antitumor Activity of a Novel pH-Activated Polymeric Drug Delivery System for Doxorubicin

BACKGROUND: Conventional chemotherapy agent such as doxorubicin (DOX) is of limited clinical use because of its inherently low selectivity, which can lead to systemic toxicity in normal healthy tissue. METHODS: A pH stimuli-sensitive conjugate based on polyethylene glycol (PEG) with covalently attac...

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Detalles Bibliográficos
Autores principales:	Huan, Menglei, Zhang, Bangle, Teng, Zenghui, Cui, Han, Wang, Jieping, Liu, Xinyou, Xia, Hui, Zhou, Siyuan, Mei, Qibing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3454402/ https://www.ncbi.nlm.nih.gov/pubmed/23028490 http://dx.doi.org/10.1371/journal.pone.0044116

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