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Finite Element Study of the Mechanical Response in Spinal Cord during the Thoracolumbar Burst Fracture

BACKGROUND: The mechanical response of the spinal cord during burst fracture was seldom quantitatively addressed and only few studies look into the internal strain of the white and grey matters within the spinal cord during thoracolumbar burst fracture (TLBF). The aim of the study is to investigate...

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Autores principales: Yan, Ya-Bo, Qi, Wei, Wu, Zi-Xiang, Qiu, Tian-Xia, Teo, Ee-Chon, Lei, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3454413/
https://www.ncbi.nlm.nih.gov/pubmed/23028426
http://dx.doi.org/10.1371/journal.pone.0041397
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author Yan, Ya-Bo
Qi, Wei
Wu, Zi-Xiang
Qiu, Tian-Xia
Teo, Ee-Chon
Lei, Wei
author_facet Yan, Ya-Bo
Qi, Wei
Wu, Zi-Xiang
Qiu, Tian-Xia
Teo, Ee-Chon
Lei, Wei
author_sort Yan, Ya-Bo
collection PubMed
description BACKGROUND: The mechanical response of the spinal cord during burst fracture was seldom quantitatively addressed and only few studies look into the internal strain of the white and grey matters within the spinal cord during thoracolumbar burst fracture (TLBF). The aim of the study is to investigate the mechanical response of the spinal cord during TLBF and correlate the percent canal compromise (PCC) with the strain in the spinal cord. METHODOLOGY/PRINCIPAL FINDINGS: A three-dimensional (3D) finite element (FE) model of human T12-L1 spinal cord with visco-elastic property was generated based on the transverse sections images of spinal cord, and the model was validated against published literatures under static uniaxial tension and compression. With the validated model, a TLBF simulation was performed to compute the mechanical strain in the spinal cord with the PCC. Linear regressions between PCC and strain in the spinal cord show that at the initial stage, with the PCC at 20%, and 45%, the corresponding mechanical strains in ventral grey, dorsal grey, ventral white, dorsal white matters were 0.06, 0.04, 0.12, 0.06, and increased to 0.14, 0.12, 0.23, and 0.13, respectively. At the recoiled stage, when the PCC was decreased from 45% to 20%, the corresponding strains were reduced to 0.03, 0.02, 0.04 and 0.03. The strain was correlated well with PCC. CONCLUSIONS/SIGNIFICANCE: The simulation shows that the strain in the spinal cord correlated well with the PCC, and the mechanical strains in the ventral regions are higher than those in the dorsal regions of spinal cord tissue during burst fracture, suggesting that the ventral regions of the spinal cord may susceptible to injury than the dorsal regions.
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spelling pubmed-34544132012-10-01 Finite Element Study of the Mechanical Response in Spinal Cord during the Thoracolumbar Burst Fracture Yan, Ya-Bo Qi, Wei Wu, Zi-Xiang Qiu, Tian-Xia Teo, Ee-Chon Lei, Wei PLoS One Research Article BACKGROUND: The mechanical response of the spinal cord during burst fracture was seldom quantitatively addressed and only few studies look into the internal strain of the white and grey matters within the spinal cord during thoracolumbar burst fracture (TLBF). The aim of the study is to investigate the mechanical response of the spinal cord during TLBF and correlate the percent canal compromise (PCC) with the strain in the spinal cord. METHODOLOGY/PRINCIPAL FINDINGS: A three-dimensional (3D) finite element (FE) model of human T12-L1 spinal cord with visco-elastic property was generated based on the transverse sections images of spinal cord, and the model was validated against published literatures under static uniaxial tension and compression. With the validated model, a TLBF simulation was performed to compute the mechanical strain in the spinal cord with the PCC. Linear regressions between PCC and strain in the spinal cord show that at the initial stage, with the PCC at 20%, and 45%, the corresponding mechanical strains in ventral grey, dorsal grey, ventral white, dorsal white matters were 0.06, 0.04, 0.12, 0.06, and increased to 0.14, 0.12, 0.23, and 0.13, respectively. At the recoiled stage, when the PCC was decreased from 45% to 20%, the corresponding strains were reduced to 0.03, 0.02, 0.04 and 0.03. The strain was correlated well with PCC. CONCLUSIONS/SIGNIFICANCE: The simulation shows that the strain in the spinal cord correlated well with the PCC, and the mechanical strains in the ventral regions are higher than those in the dorsal regions of spinal cord tissue during burst fracture, suggesting that the ventral regions of the spinal cord may susceptible to injury than the dorsal regions. Public Library of Science 2012-09-24 /pmc/articles/PMC3454413/ /pubmed/23028426 http://dx.doi.org/10.1371/journal.pone.0041397 Text en © 2012 Yan et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Yan, Ya-Bo
Qi, Wei
Wu, Zi-Xiang
Qiu, Tian-Xia
Teo, Ee-Chon
Lei, Wei
Finite Element Study of the Mechanical Response in Spinal Cord during the Thoracolumbar Burst Fracture
title Finite Element Study of the Mechanical Response in Spinal Cord during the Thoracolumbar Burst Fracture
title_full Finite Element Study of the Mechanical Response in Spinal Cord during the Thoracolumbar Burst Fracture
title_fullStr Finite Element Study of the Mechanical Response in Spinal Cord during the Thoracolumbar Burst Fracture
title_full_unstemmed Finite Element Study of the Mechanical Response in Spinal Cord during the Thoracolumbar Burst Fracture
title_short Finite Element Study of the Mechanical Response in Spinal Cord during the Thoracolumbar Burst Fracture
title_sort finite element study of the mechanical response in spinal cord during the thoracolumbar burst fracture
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3454413/
https://www.ncbi.nlm.nih.gov/pubmed/23028426
http://dx.doi.org/10.1371/journal.pone.0041397
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