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A Polymeric Protein Induces Specific Cytotoxicity in a TLR4 Dependent Manner in the Absence of Adjuvants

Lumazine synthase from Brucella spp. (BLS) is a highly immunogenic decameric protein. It is possible to insert foreign peptides or proteins at its ten-amino acid termini. These chimeras elicit systemic and oral immunity without adjuvants, which are commonly needed in the formulation of subunit-based...

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Detalles Bibliográficos
Autores principales:	Berguer, Paula M., Alzogaray, Vanina A., Rossi, Andrés Hugo, Mundiñano, Juliana, Piazzon, Isabel, Goldbaum, Fernando A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3454435/ https://www.ncbi.nlm.nih.gov/pubmed/23029192 http://dx.doi.org/10.1371/journal.pone.0045705

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