Sub-inhibitory concentrations of vancomycin prevent quinolone-resistance in a penicillin-resistant isolate of Streptococcus pneumoniae

BACKGROUND: The continuous spread of penicillin-resistant pneumococci represents a permanent threat in the treatment of pneumococcal infections, especially when strains show additional resistance to quinolones. The main objective of this study was to determine a treatment modality impeding the emerg...

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Autores principales: Cottagnoud, Philippe, Entenza, Jose M, Cottagnoud, Marianne, Que, Yok-Ai, Moreillon, Philippe, Täuber, Martin G
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2001
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC34550/
https://www.ncbi.nlm.nih.gov/pubmed/11454238
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author Cottagnoud, Philippe
Entenza, Jose M
Cottagnoud, Marianne
Que, Yok-Ai
Moreillon, Philippe
Täuber, Martin G
author_facet Cottagnoud, Philippe
Entenza, Jose M
Cottagnoud, Marianne
Que, Yok-Ai
Moreillon, Philippe
Täuber, Martin G
author_sort Cottagnoud, Philippe
collection PubMed
description BACKGROUND: The continuous spread of penicillin-resistant pneumococci represents a permanent threat in the treatment of pneumococcal infections, especially when strains show additional resistance to quinolones. The main objective of this study was to determine a treatment modality impeding the emergence of quinolone resistance. RESULTS: Exposure of a penicillin-resistant pneumococcus to increasing concentrations of trovafloxacin or ciprofloxacin selected for mutants resistant to these drugs. In the presence of sub-inhibitory concentrations of vancomycin, development of trovafloxacin-resistance and high-level ciprofloxacin-resistance were prevented. CONCLUSIONS: Considering the risk of quinolone-resistance in pneumococci, the observation might be of clinical importance.
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spelling pubmed-345502001-07-16 Sub-inhibitory concentrations of vancomycin prevent quinolone-resistance in a penicillin-resistant isolate of Streptococcus pneumoniae Cottagnoud, Philippe Entenza, Jose M Cottagnoud, Marianne Que, Yok-Ai Moreillon, Philippe Täuber, Martin G BMC Microbiol Research Article BACKGROUND: The continuous spread of penicillin-resistant pneumococci represents a permanent threat in the treatment of pneumococcal infections, especially when strains show additional resistance to quinolones. The main objective of this study was to determine a treatment modality impeding the emergence of quinolone resistance. RESULTS: Exposure of a penicillin-resistant pneumococcus to increasing concentrations of trovafloxacin or ciprofloxacin selected for mutants resistant to these drugs. In the presence of sub-inhibitory concentrations of vancomycin, development of trovafloxacin-resistance and high-level ciprofloxacin-resistance were prevented. CONCLUSIONS: Considering the risk of quinolone-resistance in pneumococci, the observation might be of clinical importance. BioMed Central 2001-07-02 /pmc/articles/PMC34550/ /pubmed/11454238 Text en Copyright © 2001 Cottagnoud et al, licensee BioMed Central Ltd.
spellingShingle Research Article
Cottagnoud, Philippe
Entenza, Jose M
Cottagnoud, Marianne
Que, Yok-Ai
Moreillon, Philippe
Täuber, Martin G
Sub-inhibitory concentrations of vancomycin prevent quinolone-resistance in a penicillin-resistant isolate of Streptococcus pneumoniae
title Sub-inhibitory concentrations of vancomycin prevent quinolone-resistance in a penicillin-resistant isolate of Streptococcus pneumoniae
title_full Sub-inhibitory concentrations of vancomycin prevent quinolone-resistance in a penicillin-resistant isolate of Streptococcus pneumoniae
title_fullStr Sub-inhibitory concentrations of vancomycin prevent quinolone-resistance in a penicillin-resistant isolate of Streptococcus pneumoniae
title_full_unstemmed Sub-inhibitory concentrations of vancomycin prevent quinolone-resistance in a penicillin-resistant isolate of Streptococcus pneumoniae
title_short Sub-inhibitory concentrations of vancomycin prevent quinolone-resistance in a penicillin-resistant isolate of Streptococcus pneumoniae
title_sort sub-inhibitory concentrations of vancomycin prevent quinolone-resistance in a penicillin-resistant isolate of streptococcus pneumoniae
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC34550/
https://www.ncbi.nlm.nih.gov/pubmed/11454238
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