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Fragment Screening at Adenosine-A(3) Receptors in Living Cells Using a Fluorescence-Based Binding Assay

G protein-coupled receptors (GPCRs) comprise the largest family of transmembrane proteins. For GPCR drug discovery, it is important that ligand affinity is determined in the correct cellular environment and preferably using an unmodified receptor. We developed a live cell high-content screening assa...

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Detalles Bibliográficos
Autores principales:	Stoddart, Leigh A., Vernall, Andrea J., Denman, Jessica L., Briddon, Stephen J., Kellam, Barrie, Hill, Stephen J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3456874/ https://www.ncbi.nlm.nih.gov/pubmed/22999879 http://dx.doi.org/10.1016/j.chembiol.2012.07.014

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