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Single-dose pharmacokinetic and toxicity analysis of pyrrole–imidazole polyamides in mice

PURPOSE: Pyrrole–imidazole (Py-Im) polyamides are programmable, sequence-specific DNA minor groove–binding ligands. Previous work in cell culture has shown that various polyamides can be used to modulate the transcriptional programs of oncogenic transcription factors. In this study, two hairpin poly...

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Detalles Bibliográficos
Autores principales:	Synold, Timothy W., Xi, Bixin, Wu, Jun, Yen, Yun, Li, Benjamin C., Yang, Fei, Phillips, John W., Nickols, Nicholas G., Dervan, Peter B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2012
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3456924/ https://www.ncbi.nlm.nih.gov/pubmed/22907527 http://dx.doi.org/10.1007/s00280-012-1954-3

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