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Blockade of the brain histamine H3 receptor by JNJ-39220675: preclinical PET studies with [(11)C]GSK189254 in anesthetized baboon
RATIONALE: The preclinical characterization of a series of aryloxypyridine amides has identified JNJ-39220675 ((4-cyclobutyl-1,4-diazepan-1-yl)(6-(4-fluorophenoxy)pyridin-3-yl)methanone) as a high-affinity histamine H(3) receptor antagonist and a candidate for further drug development particularly i...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer-Verlag
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3456925/ https://www.ncbi.nlm.nih.gov/pubmed/22614669 http://dx.doi.org/10.1007/s00213-012-2733-x |