miRNAs regulate stem cell self-renewal and differentiation

Stem cells undergo symmetric and asymmetric divisions to generate differentiated cells and more stem cells. The balance between self-renewal and differentiation of stem cells is controlled by transcription factors, epigenetic regulatory networks, and microRNAs (miRNAs). Herein the miRNA involvement...

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Detalles Bibliográficos
Autores principales: Yu, Zuoren, Li, Yuan, Fan, Huimin, Liu, Zhongmin, Pestell, Richard G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457037/
https://www.ncbi.nlm.nih.gov/pubmed/23056008
http://dx.doi.org/10.3389/fgene.2012.00191
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author Yu, Zuoren
Li, Yuan
Fan, Huimin
Liu, Zhongmin
Pestell, Richard G.
author_facet Yu, Zuoren
Li, Yuan
Fan, Huimin
Liu, Zhongmin
Pestell, Richard G.
author_sort Yu, Zuoren
collection PubMed
description Stem cells undergo symmetric and asymmetric divisions to generate differentiated cells and more stem cells. The balance between self-renewal and differentiation of stem cells is controlled by transcription factors, epigenetic regulatory networks, and microRNAs (miRNAs). Herein the miRNA involvement in the regulation of stem cell self-renewal and differentiation is summarized. miRNA contribution to malignancy through regulating cancer stem cells is described. In addition, the reciprocal associations between miRNAs and epigenetic modifications in control of stem cell fate are discussed.
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spelling pubmed-34570372012-10-09 miRNAs regulate stem cell self-renewal and differentiation Yu, Zuoren Li, Yuan Fan, Huimin Liu, Zhongmin Pestell, Richard G. Front Genet Genetics Stem cells undergo symmetric and asymmetric divisions to generate differentiated cells and more stem cells. The balance between self-renewal and differentiation of stem cells is controlled by transcription factors, epigenetic regulatory networks, and microRNAs (miRNAs). Herein the miRNA involvement in the regulation of stem cell self-renewal and differentiation is summarized. miRNA contribution to malignancy through regulating cancer stem cells is described. In addition, the reciprocal associations between miRNAs and epigenetic modifications in control of stem cell fate are discussed. Frontiers Research Foundation 2012-09-25 /pmc/articles/PMC3457037/ /pubmed/23056008 http://dx.doi.org/10.3389/fgene.2012.00191 Text en Copyright © Yu, Li, Fan, Liu and Pestell. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) , which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Genetics
Yu, Zuoren
Li, Yuan
Fan, Huimin
Liu, Zhongmin
Pestell, Richard G.
miRNAs regulate stem cell self-renewal and differentiation
title miRNAs regulate stem cell self-renewal and differentiation
title_full miRNAs regulate stem cell self-renewal and differentiation
title_fullStr miRNAs regulate stem cell self-renewal and differentiation
title_full_unstemmed miRNAs regulate stem cell self-renewal and differentiation
title_short miRNAs regulate stem cell self-renewal and differentiation
title_sort mirnas regulate stem cell self-renewal and differentiation
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457037/
https://www.ncbi.nlm.nih.gov/pubmed/23056008
http://dx.doi.org/10.3389/fgene.2012.00191
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AT fanhuimin mirnasregulatestemcellselfrenewalanddifferentiation
AT liuzhongmin mirnasregulatestemcellselfrenewalanddifferentiation
AT pestellrichardg mirnasregulatestemcellselfrenewalanddifferentiation

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