Systemic Lupus Erythematosus Accompanied by Psoriasis Induces IL-27-Producing Cells in Both Affected Areas of the Skin

IL-27 is mainly produced by activated antigen-presenting cells (APCs), and has been reported in various Th1/Th17-mediated inflammatory diseases, including psoriasis, and even in Th2-complexed disease, such as systemic lupus erythematosus (SLE). We describe a 51-year-old Japanese man with SLE accompa...

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Autores principales: Tojo, Gen-ichi, Fujimura, Taku, Kambayashi, Yumi, Aiba, Setsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2012
Materias:
Published online: August, 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457044/
https://www.ncbi.nlm.nih.gov/pubmed/23071464
http://dx.doi.org/10.1159/000342803
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author Tojo, Gen-ichi
Fujimura, Taku
Kambayashi, Yumi
Aiba, Setsuya
author_facet Tojo, Gen-ichi
Fujimura, Taku
Kambayashi, Yumi
Aiba, Setsuya
author_sort Tojo, Gen-ichi
collection PubMed
description IL-27 is mainly produced by activated antigen-presenting cells (APCs), and has been reported in various Th1/Th17-mediated inflammatory diseases, including psoriasis, and even in Th2-complexed disease, such as systemic lupus erythematosus (SLE). We describe a 51-year-old Japanese man with SLE accompanied by psoriasis. Interestingly, immunohistochemical staining revealed the existence of IL-27-producing cells in biopsy specimens from both SLE and psoriasis. Our findings might suggest relationships between IL-27 and the pathogenesis of these inflammatory diseases.
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spelling pubmed-34570442012-10-15 Systemic Lupus Erythematosus Accompanied by Psoriasis Induces IL-27-Producing Cells in Both Affected Areas of the Skin Tojo, Gen-ichi Fujimura, Taku Kambayashi, Yumi Aiba, Setsuya Case Rep Dermatol Published online: August, 2012 IL-27 is mainly produced by activated antigen-presenting cells (APCs), and has been reported in various Th1/Th17-mediated inflammatory diseases, including psoriasis, and even in Th2-complexed disease, such as systemic lupus erythematosus (SLE). We describe a 51-year-old Japanese man with SLE accompanied by psoriasis. Interestingly, immunohistochemical staining revealed the existence of IL-27-producing cells in biopsy specimens from both SLE and psoriasis. Our findings might suggest relationships between IL-27 and the pathogenesis of these inflammatory diseases. S. Karger AG 2012-08-30 /pmc/articles/PMC3457044/ /pubmed/23071464 http://dx.doi.org/10.1159/000342803 Text en Copyright © 2012 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published online: August, 2012
Tojo, Gen-ichi
Fujimura, Taku
Kambayashi, Yumi
Aiba, Setsuya
Systemic Lupus Erythematosus Accompanied by Psoriasis Induces IL-27-Producing Cells in Both Affected Areas of the Skin
title Systemic Lupus Erythematosus Accompanied by Psoriasis Induces IL-27-Producing Cells in Both Affected Areas of the Skin
title_full Systemic Lupus Erythematosus Accompanied by Psoriasis Induces IL-27-Producing Cells in Both Affected Areas of the Skin
title_fullStr Systemic Lupus Erythematosus Accompanied by Psoriasis Induces IL-27-Producing Cells in Both Affected Areas of the Skin
title_full_unstemmed Systemic Lupus Erythematosus Accompanied by Psoriasis Induces IL-27-Producing Cells in Both Affected Areas of the Skin
title_short Systemic Lupus Erythematosus Accompanied by Psoriasis Induces IL-27-Producing Cells in Both Affected Areas of the Skin
title_sort systemic lupus erythematosus accompanied by psoriasis induces il-27-producing cells in both affected areas of the skin
topic Published online: August, 2012
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457044/
https://www.ncbi.nlm.nih.gov/pubmed/23071464
http://dx.doi.org/10.1159/000342803
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