Cargando…

Cyclical modulation of human ventricular repolarization by respiration

Background: Respiratory modulation of autonomic input to the sinus node results in cyclical modulation of heart rate, known as respiratory sinus arrhythmia (RSA). We hypothesized that the respiratory cycle may also exert cyclical modulation on ventricular repolarization, which may be separately meas...

Descripción completa

Detalles Bibliográficos
Autores principales: Hanson, Ben, Gill, Jaswinder, Western, David, Gilbey, Michael P., Bostock, Julian, Boyett, Mark R., Zhang, Henggui, Coronel, Ruben, Taggart, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457072/
https://www.ncbi.nlm.nih.gov/pubmed/23055983
http://dx.doi.org/10.3389/fphys.2012.00379
_version_ 1782244538582040576
author Hanson, Ben
Gill, Jaswinder
Western, David
Gilbey, Michael P.
Bostock, Julian
Boyett, Mark R.
Zhang, Henggui
Coronel, Ruben
Taggart, Peter
author_facet Hanson, Ben
Gill, Jaswinder
Western, David
Gilbey, Michael P.
Bostock, Julian
Boyett, Mark R.
Zhang, Henggui
Coronel, Ruben
Taggart, Peter
author_sort Hanson, Ben
collection PubMed
description Background: Respiratory modulation of autonomic input to the sinus node results in cyclical modulation of heart rate, known as respiratory sinus arrhythmia (RSA). We hypothesized that the respiratory cycle may also exert cyclical modulation on ventricular repolarization, which may be separately measurable using local endocardial recordings. Methods and Results: The study included 16 subjects with normal ventricles undergoing routine clinical electrophysiological procedures for supraventricular arrhythmias. Unipolar electrograms were recorded from 10 right and 10 left ventricular endocardial sites. Breathing was voluntarily regulated at 5 fixed frequencies (6, 9, 12, 15, and 30 breaths per min) and heart rate was clamped by RV pacing. Activation-recovery intervals (ARI: a surrogate for APD) exhibited significant (p < 0.025) cyclical variation at the respiratory frequency in all subjects; ARI shortened with inspiration and lengthened with expiration. Peak-to-peak ARI variation ranged from 0–26 ms; the spatial pattern varied with subject. Arterial blood pressure also oscillated at the respiratory frequency (p < 0.025) and lagged behind respiration by between 1.5 s and 0.65 s from slowest to fastest breathing rates respectively. Systolic oscillation amplitude was significantly greater than diastolic (14 ± 5 vs. 8 ± 4 mm Hg ± SD, p < 0.001). Conclusions: Observations in humans with healthy ventricles using multiple left and right ventricular endocardial recordings showed that ARI action potential duration (APD) varied cyclically with respiration.
format Online
Article
Text
id pubmed-3457072
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-34570722012-10-09 Cyclical modulation of human ventricular repolarization by respiration Hanson, Ben Gill, Jaswinder Western, David Gilbey, Michael P. Bostock, Julian Boyett, Mark R. Zhang, Henggui Coronel, Ruben Taggart, Peter Front Physiol Physiology Background: Respiratory modulation of autonomic input to the sinus node results in cyclical modulation of heart rate, known as respiratory sinus arrhythmia (RSA). We hypothesized that the respiratory cycle may also exert cyclical modulation on ventricular repolarization, which may be separately measurable using local endocardial recordings. Methods and Results: The study included 16 subjects with normal ventricles undergoing routine clinical electrophysiological procedures for supraventricular arrhythmias. Unipolar electrograms were recorded from 10 right and 10 left ventricular endocardial sites. Breathing was voluntarily regulated at 5 fixed frequencies (6, 9, 12, 15, and 30 breaths per min) and heart rate was clamped by RV pacing. Activation-recovery intervals (ARI: a surrogate for APD) exhibited significant (p < 0.025) cyclical variation at the respiratory frequency in all subjects; ARI shortened with inspiration and lengthened with expiration. Peak-to-peak ARI variation ranged from 0–26 ms; the spatial pattern varied with subject. Arterial blood pressure also oscillated at the respiratory frequency (p < 0.025) and lagged behind respiration by between 1.5 s and 0.65 s from slowest to fastest breathing rates respectively. Systolic oscillation amplitude was significantly greater than diastolic (14 ± 5 vs. 8 ± 4 mm Hg ± SD, p < 0.001). Conclusions: Observations in humans with healthy ventricles using multiple left and right ventricular endocardial recordings showed that ARI action potential duration (APD) varied cyclically with respiration. Frontiers Media S.A. 2012-09-24 /pmc/articles/PMC3457072/ /pubmed/23055983 http://dx.doi.org/10.3389/fphys.2012.00379 Text en Copyright © 2012 Hanson, Gill, Western, Gilbey, Bostock, Boyett, Zhang, Coronel and Taggart. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Physiology
Hanson, Ben
Gill, Jaswinder
Western, David
Gilbey, Michael P.
Bostock, Julian
Boyett, Mark R.
Zhang, Henggui
Coronel, Ruben
Taggart, Peter
Cyclical modulation of human ventricular repolarization by respiration
title Cyclical modulation of human ventricular repolarization by respiration
title_full Cyclical modulation of human ventricular repolarization by respiration
title_fullStr Cyclical modulation of human ventricular repolarization by respiration
title_full_unstemmed Cyclical modulation of human ventricular repolarization by respiration
title_short Cyclical modulation of human ventricular repolarization by respiration
title_sort cyclical modulation of human ventricular repolarization by respiration
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457072/
https://www.ncbi.nlm.nih.gov/pubmed/23055983
http://dx.doi.org/10.3389/fphys.2012.00379
work_keys_str_mv AT hansonben cyclicalmodulationofhumanventricularrepolarizationbyrespiration
AT gilljaswinder cyclicalmodulationofhumanventricularrepolarizationbyrespiration
AT westerndavid cyclicalmodulationofhumanventricularrepolarizationbyrespiration
AT gilbeymichaelp cyclicalmodulationofhumanventricularrepolarizationbyrespiration
AT bostockjulian cyclicalmodulationofhumanventricularrepolarizationbyrespiration
AT boyettmarkr cyclicalmodulationofhumanventricularrepolarizationbyrespiration
AT zhanghenggui cyclicalmodulationofhumanventricularrepolarizationbyrespiration
AT coronelruben cyclicalmodulationofhumanventricularrepolarizationbyrespiration
AT taggartpeter cyclicalmodulationofhumanventricularrepolarizationbyrespiration