Cargando…

Vaccine Development to Treat Alzheimer's Disease Neuropathology in APP/PS1 Transgenic Mice

A novel vaccine addressing the major hallmarks of Alzheimer's disease (AD), senile plaque-like deposits of amyloid beta-protein (Aβ), neurofibrillary tangle-like structures, and glial proinflammatory cytokines, has been developed. The present vaccine takes a new approach to circumvent failures...

Descripción completa

Detalles Bibliográficos
Autores principales:	Carrera, Iván, Etcheverría, Ignacio, Fernández-Novoa, Lucía, Lombardi, Valter, Cacabelos, Ramón, Vigo, Carmen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457670/ https://www.ncbi.nlm.nih.gov/pubmed/23024882 http://dx.doi.org/10.1155/2012/376138

Ejemplares similares

Immunocytochemical Characterization of Alzheimer Disease Hallmarks in APP/PS1 Transgenic Mice Treated with a New Anti-Amyloid-β Vaccine
por: Carrera, Iván, et al.
Publicado: (2013)

Immunocytochemical Characterization of Alzheimer’s Disease Hallmarks in APP/PS1 Transgenic Mice Treated with a New Anti-Amyloid-β Vaccine
por: Carrera, Ivan, et al.
Publicado: (2014)

A Comparative Evaluation of a Novel Vaccine in APP/PS1 Mouse Models of Alzheimer's Disease
por: Carrera, Iván, et al.
Publicado: (2015)

Prevention of Chronic Experimental Colitis Induced by Dextran Sulphate Sodium (DSS) in Mice Treated with FR91
por: Lombardi, Valter R. M., et al.
Publicado: (2012)

Epigenetic Studies in the Male APP/BIN1/COPS5 Triple-Transgenic Mouse Model of Alzheimer’s Disease
por: Martínez-Iglesias, Olaia, et al.
Publicado: (2022)

Neuropathological and behavioral features of an APP/PS1/MAPT (6xTg) transgenic model of Alzheimer’s disease
por: Tag, Sung Hyun, et al.
Publicado: (2022)

In vitro and in vivo cytotoxic effect of AntiGan against tumor cells
por: Lombardi, Valter R.M., et al.
Publicado: (2018)

In Vitro Screening for Cytotoxic Activity of Herbal Extracts
por: Lombardi, Valter R. M., et al.
Publicado: (2017)

Naringin Dihydrochalcone Ameliorates Cognitive Deficits and Neuropathology in APP/PS1 Transgenic Mice
por: Yang, Wenjuan, et al.
Publicado: (2018)

Amelioration of Behavioral Impairments and Neuropathology by Antiepileptic Drug Topiramate in a Transgenic Alzheimer’s Disease Model Mice, APP/PS1
por: Owona, Brice Ayissi, et al.
Publicado: (2019)

Zerumbone ameliorates behavioral impairments and neuropathology in transgenic APP/PS1 mice by suppressing MAPK signaling
por: Li, Lei, et al.
Publicado: (2020)

DNA Methylation in Neurodegenerative and Cerebrovascular Disorders
por: Martínez-Iglesias, Olaia, et al.
Publicado: (2020)

Genomics of Dementia: APOE- and CYP2D6-Related Pharmacogenetics
por: Cacabelos, Ramón, et al.
Publicado: (2012)

Influence of Pathogenic and Metabolic Genes on the Pharmacogenetics of Mood Disorders in Alzheimer’s Disease
por: Cacabelos, Ramón, et al.
Publicado: (2021)

Resting-State Network Disruption and APOE Genotype in Alzheimer's Disease: A lagged Functional Connectivity Study
por: Canuet, Leonides, et al.
Publicado: (2012)

Immune-mediated platelet depletion augments Alzheimer’s disease neuropathological hallmarks in APP-PS1 mice
por: de Sousa, Diana M. Bessa, et al.
Publicado: (2023)

Nutrition, Health, and Disease: Role of Selected Marine and Vegetal Nutraceuticals
por: Corzo, Lola, et al.
Publicado: (2020)

Exposure to fluoride aggravates the impairment in learning and memory and neuropathological lesions in mice carrying the APP/PS1 double-transgenic mutation
por: Cao, Kun, et al.
Publicado: (2019)

Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice
por: Hiltunen, Mikko, et al.
Publicado: (2012)

Untargeted lipidomics reveals progression of early Alzheimer’s disease in APP/PS1 transgenic mice
por: Zhang, Xueju, et al.
Publicado: (2020)

Future Trends in the Pharmacogenomics of Brain Disorders and Dementia: Influence of APOE and CYP2D6 Variants
por: Cacabelos, Ramón, et al.
Publicado: (2010)

Neuroprotective Effect of Nosustrophine in a 3xTg Mouse Model of Alzheimer’s Disease
por: Carrera, Iván, et al.
Publicado: (2023)

Nosustrophine: An Epinutraceutical Bioproduct with Effects on DNA Methylation, Histone Acetylation and Sirtuin Expression in Alzheimer’s Disease
por: Martínez-Iglesias, Olaia, et al.
Publicado: (2022)

Humulus japonicus inhibits the progression of Alzheimer's disease in a APP/PS1 transgenic mouse model
por: Park, Tae-Shin, et al.
Publicado: (2017)

Fecal microbiota transplantation alleviated Alzheimer’s disease-like pathogenesis in APP/PS1 transgenic mice
por: Sun, Jing, et al.
Publicado: (2019)

Ovocystatin Induced Changes in Expression of Alzheimer’s Disease Relevant Proteins in APP/PS1 Transgenic Mice
por: Stanczykiewicz, Bartlomiej, et al.
Publicado: (2022)

Current Drugs and Potential Future Neuroprotective Compounds for Parkinson’s Disease
por: Carrera, Iván, et al.
Publicado: (2019)

Alzheimer disease neuropathology in a patient previously treated with aducanumab
por: Plowey, Edward D., et al.
Publicado: (2022)

Chronic diabetic states worsen Alzheimer neuropathology and cognitive deficits accompanying disruption of calcium signaling in leptin-deficient APP/PS1 mice
por: Zhang, Shuai, et al.
Publicado: (2017)

Effects of FR-91 on Immune Cells from Healthy Individuals and from Patients with Non-Hodgkin Lymphoma
por: Lombardi, V. R. M., et al.
Publicado: (2009)

Natural Bioactive Products as Epigenetic Modulators for Treating Neurodegenerative Disorders
por: Martínez-Iglesias, Olaia, et al.
Publicado: (2023)

Personalized Medicine of Alzheimer’s Disease
por: Cacabelos, Ramón, et al.
Publicado: (2014)

Effects of (−)Epicatechin on the Pathology of APP/PS1 Transgenic Mice
por: Zeng, Yue-Qin, et al.
Publicado: (2014)

A longitudinal assessment of retinal function and structure in the APP/PS1 transgenic mouse model of Alzheimer’s disease
por: Georgevsky, Dana, et al.
Publicado: (2019)

Author Correction: Untargeted lipidomics reveals progression of early Alzheimer’s disease in APP/PS1 transgenic mice
por: Zhang, Xueju, et al.
Publicado: (2021)

Histamine and Immune Biomarkers in CNS Disorders
por: Cacabelos, Ramón, et al.
Publicado: (2016)

Neuropathology of the Brainstem to Mechanistically Understand and to Treat Alzheimer’s Disease
por: Patthy, Ágoston, et al.
Publicado: (2021)

Transplantation of bone marrow derived macrophages reduces markers of neuropathology in an APP/PS1 mouse model
por: Costa-Marques, Luís, et al.
Publicado: (2019)

Neuropathology of transgenic HD animal models
por: Li, Xiaojiang, et al.
Publicado: (2012)

Commentary: L-3-n-butylphthalide Rescues Hippocampal Synaptic Failure and Attenuates Neuropathology in Aged APP/PS1 Mouse Model of Alzheimer's Disease
por: Bhatt, Prakash C., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_gbpjabjb3bvb4l4vo7mftdtsab