Modification of polyethylene glycol onto solid lipid nanoparticles encapsulating a novel chemotherapeutic agent (PK-L4) to enhance solubility for injection delivery

BACKGROUND: The synthetic potential chemotherapeutic agent 3-Chloro-4-[(4-methoxyphenyl) amino]furo[2,3-b]quinoline (PK-L4) is an analog of amsacrine. The half-life of PK-L4 is longer than that of amsacrine; however, PK-L4 is difficult to dissolve in aqueous media, which is problematic for administr...

Descripción completa

Detalles Bibliográficos
Autores principales: Fang, Yi-Ping, Wu, Pao-Chu, Huang, Yaw-Bin, Tzeng, Cherng-Chyi, Chen, Yeh-Long, Hung, Yu-Han, Tsai, Ming-Jun, Tsai, Yi-Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457677/
https://www.ncbi.nlm.nih.gov/pubmed/23055719
http://dx.doi.org/10.2147/IJN.S34301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457677/
https://www.ncbi.nlm.nih.gov/pubmed/23055719
http://dx.doi.org/10.2147/IJN.S34301

Ejemplares similares