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Plasmin and chymotrypsin have distinct preferences for channel activating cleavage sites in the γ subunit of the human epithelial sodium channel

Proteolytic activation of the epithelial sodium channel (ENaC) involves cleavage of its γ subunit in a critical region targeted by several proteases. Our aim was to identify cleavage sites in this region that are functionally important for activation of human ENaC by plasmin and chymotrypsin. Sequen...

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Detalles Bibliográficos
Autores principales: Haerteis, Silke, Krappitz, Matteus, Diakov, Alexei, Krappitz, Annabel, Rauh, Robert, Korbmacher, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457690/
https://www.ncbi.nlm.nih.gov/pubmed/22966015
http://dx.doi.org/10.1085/jgp.201110763

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