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Macrophages induce differentiation of plasma cells through CXCL10/IP-10
In tonsils, CD138(+) plasma cells (PCs) are surrounded by CD163(+) resident macrophages (Mϕs). We show here that human Mϕs (isolated from tonsils or generated from monocytes in vitro) drive activated B cells to differentiate into CD138(+)CD38(++) PCs through secreted CXCL10/IP-10 and VCAM-1 contact....
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457728/ https://www.ncbi.nlm.nih.gov/pubmed/22987802 http://dx.doi.org/10.1084/jem.20112142 |