Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infection

Central and peripheral tolerance prevent autoimmunity by deleting the most aggressive CD8(+) T cells but they spare cells that react weakly to tissue-restricted antigen (TRA). To reveal the functional characteristics of these spared cells, we generated a transgenic mouse expressing the TCR of a TRA-...

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Detalles Bibliográficos
Autores principales: Enouz, Sarah, Carrié, Lucie, Merkler, Doron, Bevan, Michael J., Zehn, Dietmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457731/
https://www.ncbi.nlm.nih.gov/pubmed/22987800
http://dx.doi.org/10.1084/jem.20120905

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457731/
https://www.ncbi.nlm.nih.gov/pubmed/22987800
http://dx.doi.org/10.1084/jem.20120905

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