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TRAF-interacting protein (TRIP) negatively regulates IFN-β production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1

TANK-binding kinase 1 (TBK1) plays an essential role in Toll-like receptor (TLR)– and retinoic acid–inducible gene I (RIG-I)–mediated induction of type I interferon (IFN; IFN-α/β) and host antiviral responses. How TBK1 activity is negatively regulated remains largely unknown. We report that TNF rece...

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Detalles Bibliográficos
Autores principales:	Zhang, Meng, Wang, Lijuan, Zhao, Xueying, Zhao, Kai, Meng, Hong, Zhao, Wei, Gao, Chengjiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2012
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457734/ https://www.ncbi.nlm.nih.gov/pubmed/22945920 http://dx.doi.org/10.1084/jem.20120024

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