Reduced TCR signaling potential impairs negative selection but does not result in autoimmune disease

Negative selection and regulatory T (T reg) cell development are two thymus-dependent processes necessary for the enforcement of self-tolerance, and both require high-affinity interactions between the T cell receptor (TCR) and self-ligands. However, it remains unclear if they are similarly impacted...

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Detalles Bibliográficos
Autores principales: Hwang, SuJin, Song, Ki-Duk, Lesourne, Renaud, Lee, Jan, Pinkhasov, Julia, Li, LiQi, El-Khoury, Dalal, Love, Paul E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457736/
https://www.ncbi.nlm.nih.gov/pubmed/22945921
http://dx.doi.org/10.1084/jem.20120058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457736/
https://www.ncbi.nlm.nih.gov/pubmed/22945921
http://dx.doi.org/10.1084/jem.20120058

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