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Predictor of poor coronary collaterals in chronic kidney disease population with significant coronary artery disease
BACKGROUND: Coronary collateral circulation plays an important role to protect myocardium from ischemia, preserve myocardial contractility and reduce cardiovascular events. Chronic kidney disease (CKD) is associated with poor coronary collateral development and cardiovascular outcome. However, limit...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457843/ https://www.ncbi.nlm.nih.gov/pubmed/22935602 http://dx.doi.org/10.1186/1471-2369-13-98 |
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author | Hsu, Po-Chao Juo, Suh-Hang Su, Ho-Ming Chen, Szu-Chia Tsai, Wei-chung Lai, Wen-Ter Sheu, Sheng-Hsiung Lin, Tsung-Hsien |
author_facet | Hsu, Po-Chao Juo, Suh-Hang Su, Ho-Ming Chen, Szu-Chia Tsai, Wei-chung Lai, Wen-Ter Sheu, Sheng-Hsiung Lin, Tsung-Hsien |
author_sort | Hsu, Po-Chao |
collection | PubMed |
description | BACKGROUND: Coronary collateral circulation plays an important role to protect myocardium from ischemia, preserve myocardial contractility and reduce cardiovascular events. Chronic kidney disease (CKD) is associated with poor coronary collateral development and cardiovascular outcome. However, limited research investigates the predictors for collateral development in the CKD population. METHODS: We evaluated 970 consecutive patients undergoing coronary angiography and 202 patients with CKD, defined as a glomerular filtration rate less than 60 ml/min/1.73 m(2), were finally analyzed. The collateral scoring system developed by Rentrop was used to classify patients into poor (grades 0 and 1) or good (grades 2 and 3) collateral group. RESULTS: The patients with poor collateral (n = 122) had a higher incidence of hypertension (82% vs 63.8%, p = 0.005), fewer diseased vessels numbers (2.1 ± 0.9 vs 2.6 ± 0.6, p < 0.001) and a trend to be diabetic (56.6% vs. 43.8%, p = 0.085) or female sex (37.7% vs. 25.0%, p = 0.067). Multivariate analysis showed hypertension (odd ratio (OR) 2.672, p = 0.006), diabetes (OR 1.956, p = 0.039) and diseased vessels numbers (OR 0.402, p < 0.001) were significant predictors of poor coronary collaterals development. Furthermore, hypertension and diabetes have a negative synergistic effect on collateral development (p = 0.004 for interaction). CONCLUSIONS: In the CKD population hypertension and diabetes might negatively influence the coronary collaterals development. |
format | Online Article Text |
id | pubmed-3457843 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-34578432012-09-26 Predictor of poor coronary collaterals in chronic kidney disease population with significant coronary artery disease Hsu, Po-Chao Juo, Suh-Hang Su, Ho-Ming Chen, Szu-Chia Tsai, Wei-chung Lai, Wen-Ter Sheu, Sheng-Hsiung Lin, Tsung-Hsien BMC Nephrol Research Article BACKGROUND: Coronary collateral circulation plays an important role to protect myocardium from ischemia, preserve myocardial contractility and reduce cardiovascular events. Chronic kidney disease (CKD) is associated with poor coronary collateral development and cardiovascular outcome. However, limited research investigates the predictors for collateral development in the CKD population. METHODS: We evaluated 970 consecutive patients undergoing coronary angiography and 202 patients with CKD, defined as a glomerular filtration rate less than 60 ml/min/1.73 m(2), were finally analyzed. The collateral scoring system developed by Rentrop was used to classify patients into poor (grades 0 and 1) or good (grades 2 and 3) collateral group. RESULTS: The patients with poor collateral (n = 122) had a higher incidence of hypertension (82% vs 63.8%, p = 0.005), fewer diseased vessels numbers (2.1 ± 0.9 vs 2.6 ± 0.6, p < 0.001) and a trend to be diabetic (56.6% vs. 43.8%, p = 0.085) or female sex (37.7% vs. 25.0%, p = 0.067). Multivariate analysis showed hypertension (odd ratio (OR) 2.672, p = 0.006), diabetes (OR 1.956, p = 0.039) and diseased vessels numbers (OR 0.402, p < 0.001) were significant predictors of poor coronary collaterals development. Furthermore, hypertension and diabetes have a negative synergistic effect on collateral development (p = 0.004 for interaction). CONCLUSIONS: In the CKD population hypertension and diabetes might negatively influence the coronary collaterals development. BioMed Central 2012-08-30 /pmc/articles/PMC3457843/ /pubmed/22935602 http://dx.doi.org/10.1186/1471-2369-13-98 Text en Copyright ©2012 Hsu et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Hsu, Po-Chao Juo, Suh-Hang Su, Ho-Ming Chen, Szu-Chia Tsai, Wei-chung Lai, Wen-Ter Sheu, Sheng-Hsiung Lin, Tsung-Hsien Predictor of poor coronary collaterals in chronic kidney disease population with significant coronary artery disease |
title | Predictor of poor coronary collaterals in chronic kidney disease population with significant coronary artery disease |
title_full | Predictor of poor coronary collaterals in chronic kidney disease population with significant coronary artery disease |
title_fullStr | Predictor of poor coronary collaterals in chronic kidney disease population with significant coronary artery disease |
title_full_unstemmed | Predictor of poor coronary collaterals in chronic kidney disease population with significant coronary artery disease |
title_short | Predictor of poor coronary collaterals in chronic kidney disease population with significant coronary artery disease |
title_sort | predictor of poor coronary collaterals in chronic kidney disease population with significant coronary artery disease |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457843/ https://www.ncbi.nlm.nih.gov/pubmed/22935602 http://dx.doi.org/10.1186/1471-2369-13-98 |
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