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Bax Activation Initiates the Assembly of a Multimeric Catalyst that Facilitates Bax Pore Formation in Mitochondrial Outer Membranes

Bax/Bak-mediated mitochondrial outer membrane permeabilization (MOMP) is essential for “intrinsic” apoptotic cell death. Published studies used synthetic liposomes to reveal an intrinsic pore-forming activity of Bax, but it is unclear how other mitochondrial outer membrane (MOM) proteins might facil...

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Detalles Bibliográficos
Autores principales:	Kushnareva, Yulia, Andreyev, Alexander Y., Kuwana, Tomomi, Newmeyer, Donald D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457932/ https://www.ncbi.nlm.nih.gov/pubmed/23049480 http://dx.doi.org/10.1371/journal.pbio.1001394

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