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Population PK/PD Model of Homocysteine Concentrations after High-Dose Methotrexate Treatment in Patients with Acute Lymphoblastic Leukemia

Elevated homocysteine concentrations have been associated with methotrexate-induced neurotoxicity. Based on methotrexate and homocysteine plasma concentrations of 494 children with acute lymphoblastic leukemia treated with high-dose methotrexate in the TOTAL XV study, a pharmacokinetic/pharmacodynam...

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Detalles Bibliográficos
Autores principales:	Rühs, Hauke, Becker, Achim, Drescher, Anne, Panetta, John C., Pui, Ching-Hon, Relling, Mary V., Jaehde, Ulrich
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457953/ https://www.ncbi.nlm.nih.gov/pubmed/23049924 http://dx.doi.org/10.1371/journal.pone.0046015

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