Effect of SNPs on Creatine Kinase Structure and Function: Identifying Potential Molecular Mechanisms for Possible Creatine Kinase Deficiency Diseases

Single-nucleotide polymorphisms (SNPs) are common genetic material changes that often occur naturally. SNPs can cause amino acid replacements that may lead to severe diseases, such as the well-known sickle-cell anemia. We constructed eight SNP mutants of human brain-type creatine kinase (CKB) based...

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Detalles Bibliográficos
Autores principales: Li, Chang, Zhang, Qian, Hu, Wei-Jiang, Mu, Hang, Lin, Zong, Ma, Long, Park, Yong-Doo, Zhou, Hai-Meng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457962/
https://www.ncbi.nlm.nih.gov/pubmed/23049898
http://dx.doi.org/10.1371/journal.pone.0045949

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