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The Cancer Exome Generated by Alternative mRNA Splicing Dilutes Predicted HLA Class I Epitope Density

Several studies have shown that cancers actively regulate alternative splicing. Altered splicing mechanisms in cancer lead to cancer-specific transcripts different from the pool of transcripts occurring only in healthy tissue. At the same time, altered presentation of HLA class I epitopes is frequen...

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Detalles Bibliográficos
Autores principales:	Stranzl, Thomas, Larsen, Mette V., Lund, Ole, Nielsen, Morten, Brunak, Søren
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458037/ https://www.ncbi.nlm.nih.gov/pubmed/23049726 http://dx.doi.org/10.1371/journal.pone.0038670

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