The CaMK4/CREB/IRS-2 Cascade Stimulates Proliferation and Inhibits Apoptosis of β-Cells

Progressive reduction in β-cell mass is responsible for the development of type 2 diabetes mellitus, and alteration in insulin receptor substrate 2 (IRS-2) abundance plays a critical role in this process. IRS-2 expression is stimulated by the transcription factor cAMP response element-binding protei...

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Detalles Bibliográficos
Autores principales: Liu, Bo, Barbosa-Sampaio, Helena, Jones, Peter M., Persaud, Shanta J., Muller, Dany S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458088/
https://www.ncbi.nlm.nih.gov/pubmed/23049845
http://dx.doi.org/10.1371/journal.pone.0045711

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458088/
https://www.ncbi.nlm.nih.gov/pubmed/23049845
http://dx.doi.org/10.1371/journal.pone.0045711

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