Saccadic eye movements evoked by optogenetic activation of primate V1

Optogenetics has advanced our understanding of the neural basis of simple behaviors in rodents and small animals. In primates, however, for which more sophisticated behavioral assays exist, optogenetic manipulations of behavior have been unsuccessful. Here, we report that monkeys reliably shift thei...

Descripción completa

Detalles Bibliográficos
Autores principales: Jazayeri, Mehrdad, Lindbloom–Brown, Zachary, Horwitz, Gregory D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458167/
https://www.ncbi.nlm.nih.gov/pubmed/22941109
http://dx.doi.org/10.1038/nn.3210
_version_ 1782244633223364608
author Jazayeri, Mehrdad
Lindbloom–Brown, Zachary
Horwitz, Gregory D.
author_facet Jazayeri, Mehrdad
Lindbloom–Brown, Zachary
Horwitz, Gregory D.
author_sort Jazayeri, Mehrdad
collection PubMed
description Optogenetics has advanced our understanding of the neural basis of simple behaviors in rodents and small animals. In primates, however, for which more sophisticated behavioral assays exist, optogenetic manipulations of behavior have been unsuccessful. Here, we report that monkeys reliably shift their gaze toward the receptive field of optically driven channelrhodopsin–2–expressing V1 neurons. This result establishes optogenetics as a viable tool for the causal analysis of behavior in primate brain.
format Online
Article
Text
id pubmed-3458167
institution National Center for Biotechnology Information
language English
publishDate 2012
record_format MEDLINE/PubMed
spelling pubmed-34581672013-04-01 Saccadic eye movements evoked by optogenetic activation of primate V1 Jazayeri, Mehrdad Lindbloom–Brown, Zachary Horwitz, Gregory D. Nat Neurosci Article Optogenetics has advanced our understanding of the neural basis of simple behaviors in rodents and small animals. In primates, however, for which more sophisticated behavioral assays exist, optogenetic manipulations of behavior have been unsuccessful. Here, we report that monkeys reliably shift their gaze toward the receptive field of optically driven channelrhodopsin–2–expressing V1 neurons. This result establishes optogenetics as a viable tool for the causal analysis of behavior in primate brain. 2012-09-02 2012-10 /pmc/articles/PMC3458167/ /pubmed/22941109 http://dx.doi.org/10.1038/nn.3210 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Jazayeri, Mehrdad
Lindbloom–Brown, Zachary
Horwitz, Gregory D.
Saccadic eye movements evoked by optogenetic activation of primate V1
title Saccadic eye movements evoked by optogenetic activation of primate V1
title_full Saccadic eye movements evoked by optogenetic activation of primate V1
title_fullStr Saccadic eye movements evoked by optogenetic activation of primate V1
title_full_unstemmed Saccadic eye movements evoked by optogenetic activation of primate V1
title_short Saccadic eye movements evoked by optogenetic activation of primate V1
title_sort saccadic eye movements evoked by optogenetic activation of primate v1
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458167/
https://www.ncbi.nlm.nih.gov/pubmed/22941109
http://dx.doi.org/10.1038/nn.3210
work_keys_str_mv AT jazayerimehrdad saccadiceyemovementsevokedbyoptogeneticactivationofprimatev1
AT lindbloombrownzachary saccadiceyemovementsevokedbyoptogeneticactivationofprimatev1
AT horwitzgregoryd saccadiceyemovementsevokedbyoptogeneticactivationofprimatev1

Ejemplares similares