PPARs Signaling and Cancer in the Gastrointestinal System

Nowadays, the study of the peroxisome proliferators activated receptors (PPARs) as potential targets for cancer prevention and therapy has gained a strong interest. From a biological point of view, the overall responsibility of PPARs in cancer development and progression is still controversial since...

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Detalles Bibliográficos
Autores principales: Pazienza, Valerio, Vinciguerra, Manlio, Mazzoccoli, Gianluigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458283/
https://www.ncbi.nlm.nih.gov/pubmed/23028383
http://dx.doi.org/10.1155/2012/560846
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author Pazienza, Valerio
Vinciguerra, Manlio
Mazzoccoli, Gianluigi
author_facet Pazienza, Valerio
Vinciguerra, Manlio
Mazzoccoli, Gianluigi
author_sort Pazienza, Valerio
collection PubMed
description Nowadays, the study of the peroxisome proliferators activated receptors (PPARs) as potential targets for cancer prevention and therapy has gained a strong interest. From a biological point of view, the overall responsibility of PPARs in cancer development and progression is still controversial since several studies report both antiproliferative and tumor-promoting actions for these signaling molecules in human cancer cells and animal models. In this paper, we discuss PPARs functions in the context of different types of gastrointestinal cancer.
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spelling pubmed-34582832012-10-01 PPARs Signaling and Cancer in the Gastrointestinal System Pazienza, Valerio Vinciguerra, Manlio Mazzoccoli, Gianluigi PPAR Res Review Article Nowadays, the study of the peroxisome proliferators activated receptors (PPARs) as potential targets for cancer prevention and therapy has gained a strong interest. From a biological point of view, the overall responsibility of PPARs in cancer development and progression is still controversial since several studies report both antiproliferative and tumor-promoting actions for these signaling molecules in human cancer cells and animal models. In this paper, we discuss PPARs functions in the context of different types of gastrointestinal cancer. Hindawi Publishing Corporation 2012 2012-09-17 /pmc/articles/PMC3458283/ /pubmed/23028383 http://dx.doi.org/10.1155/2012/560846 Text en Copyright © 2012 Valerio Pazienza et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Pazienza, Valerio
Vinciguerra, Manlio
Mazzoccoli, Gianluigi
PPARs Signaling and Cancer in the Gastrointestinal System
title PPARs Signaling and Cancer in the Gastrointestinal System
title_full PPARs Signaling and Cancer in the Gastrointestinal System
title_fullStr PPARs Signaling and Cancer in the Gastrointestinal System
title_full_unstemmed PPARs Signaling and Cancer in the Gastrointestinal System
title_short PPARs Signaling and Cancer in the Gastrointestinal System
title_sort ppars signaling and cancer in the gastrointestinal system
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458283/
https://www.ncbi.nlm.nih.gov/pubmed/23028383
http://dx.doi.org/10.1155/2012/560846
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