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Quantifying selection in high-throughput Immunoglobulin sequencing data sets
High-throughput immunoglobulin sequencing promises new insights into the somatic hypermutation and antigen-driven selection processes that underlie B-cell affinity maturation and adaptive immunity. The ability to estimate positive and negative selection from these sequence data has broad application...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458526/ https://www.ncbi.nlm.nih.gov/pubmed/22641856 http://dx.doi.org/10.1093/nar/gks457 |