Cargando…

RNA modulation of the human DNA methyltransferase 3A

DNA methyltransferase 3A (DNMT3A) is one of two human de novo DNA methyltransferases essential for transcription regulation during cellular development and differentiation. There is increasing evidence that RNA plays a role in directing DNA methylation to specific genomic locations within mammalian...

Descripción completa

Detalles Bibliográficos
Autores principales:	Holz-Schietinger, Celeste, Reich, Norbert O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458530/ https://www.ncbi.nlm.nih.gov/pubmed/22730298 http://dx.doi.org/10.1093/nar/gks537

Ejemplares similares

High fidelity DNA strand-separation is the major specificity determinant in DNA methyltransferase CcrM’s catalytic mechanism
por: Konttinen, Olivia, et al.
Publicado: (2023)

Cell cycle regulated DNA methyltransferase: fluorescent tracking of a DNA strand-separation mechanism and identification of the responsible protein motif
por: Konttinen, Olivia, et al.
Publicado: (2020)

Formation of m(2)G6 in Methanocaldococcus jannaschii tRNA catalyzed by the novel methyltransferase Trm14
por: Menezes, Sheena, et al.
Publicado: (2011)

Small RNA-mediated DNA (cytosine-5) methyltransferase 1 inhibition leads to aberrant DNA methylation
por: Zhang, Guoqiang, et al.
Publicado: (2015)

Novel non-specific DNA adenine methyltransferases
por: Drozdz, Marek, et al.
Publicado: (2012)

The human methyltransferase ZCCHC4 catalyses N(6)-methyladenosine modification of 28S ribosomal RNA
por: Pinto, Rita, et al.
Publicado: (2020)

Engineering the DNA cytosine-5 methyltransferase reaction for sequence-specific labeling of DNA
por: Lukinavičius, Gražvydas, et al.
Publicado: (2012)

Functional characterization of the human tRNA methyltransferases TRMT10A and TRMT10B
por: Vilardo, Elisa, et al.
Publicado: (2020)

The non-specific adenine DNA methyltransferase M.EcoGII
por: Murray, Iain A, et al.
Publicado: (2018)

Epigenetic disruption of ribosomal RNA genes and nucleolar architecture in DNA methyltransferase 1 (Dnmt1) deficient cells
por: Espada, Jesús, et al.
Publicado: (2007)

Direct observation of cytosine flipping and covalent catalysis in a DNA methyltransferase
por: Gerasimaitė, Rūta, et al.
Publicado: (2011)

Dynamics of RNA modification by a multi-site-specific tRNA methyltransferase
por: Hamdane, Djemel, et al.
Publicado: (2014)

Structural and functional analyses of the archaeal tRNA m(2)G/m(2)(2)G10 methyltransferase aTrm11 provide mechanistic insights into site specificity of a tRNA methyltransferase that contains common RNA-binding modules
por: Hirata, Akira, et al.
Publicado: (2016)

Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes
por: Li, Fuyang, et al.
Publicado: (2007)

Mutations of R882 change flanking sequence preferences of the DNA methyltransferase DNMT3A and cellular methylation patterns
por: Emperle, Max, et al.
Publicado: (2019)

Structural and biochemical insight into the mechanism of dual CpG site binding and methylation by the DNMT3A DNA methyltransferase
por: Emperle, Max, et al.
Publicado: (2021)

Loss of the ribosomal RNA methyltransferase NSUN5 impairs global protein synthesis and normal growth
por: Heissenberger, Clemens, et al.
Publicado: (2019)

Evolutionary transitions to new DNA methyltransferases through target site expansion and shrinkage
por: Rockah-Shmuel, Liat, et al.
Publicado: (2012)

Characterization of the dual role of Plasmodium falciparum DNA methyltransferase in regulating transcription and translation
por: Lucky, Amuza B, et al.
Publicado: (2023)

The Caulobacter crescentus DNA-(adenine-N6)-methyltransferase CcrM methylates DNA in a distributive manner
por: Albu, Razvan F., et al.
Publicado: (2012)

The tRNA recognition mechanism of the minimalist SPOUT methyltransferase, TrmL
por: Liu, Ru-Juan, et al.
Publicado: (2013)

A subcomplex of human mitochondrial RNase P is a bifunctional methyltransferase—extensive moonlighting in mitochondrial tRNA biogenesis
por: Vilardo, Elisa, et al.
Publicado: (2012)

Structural basis for substrate binding and catalytic mechanism of a human RNA:m(5)C methyltransferase NSun6
por: Liu, Ru-Juan, et al.
Publicado: (2017)

The Dnmt2 RNA methyltransferase homolog of Geobacter sulfurreducens specifically methylates tRNA-Glu
por: Shanmugam, Raghuvaran, et al.
Publicado: (2014)

The methyltransferase TrmA facilitates tRNA folding through interaction with its RNA-binding domain
por: Keffer-Wilkes, Laura Carole, et al.
Publicado: (2020)

KsgA, a 16S rRNA adenine methyltransferase, has a novel DNA glycosylase/AP lyase activity to prevent mutations in Escherichia coli
por: Zhang-Akiyama, Qiu-Mei, et al.
Publicado: (2009)

Mechanism of allosteric activation of human mRNA cap methyltransferase (RNMT) by RAM: insights from accelerated molecular dynamics simulations
por: Bueren-Calabuig, Juan A, et al.
Publicado: (2019)

The critical function of the plastid rRNA methyltransferase, CMAL, in ribosome biogenesis and plant development
por: Zou, Meijuan, et al.
Publicado: (2020)

Functional characterization of a 48 kDa Trypanosoma brucei cap 2 RNA methyltransferase
por: Hall, Megan P., et al.
Publicado: (2006)

tRNA recognition by a bacterial tRNA Xm32 modification enzyme from the SPOUT methyltransferase superfamily
por: Liu, Ru-Juan, et al.
Publicado: (2015)

A second type of N7-guanine RNA cap methyltransferase in an unusual locus of a large RNA virus genome
por: Shannon, Ashleigh, et al.
Publicado: (2022)

Structural characterization of B. subtilis m(1)A(22) tRNA methyltransferase TrmK: insights into tRNA recognition
por: Dégut, Clément, et al.
Publicado: (2019)

The geometry of DNA supercoils modulates the DNA cleavage activity of human topoisomerase I
por: Gentry, Amanda C., et al.
Publicado: (2011)

Programmable sequence-specific click-labeling of RNA using archaeal box C/D RNP methyltransferases
por: Tomkuvienė, Miglė, et al.
Publicado: (2012)

Mechanistic features of the atypical tRNA m(1)G(9) SPOUT methyltransferase, Trm10
por: Krishnamohan, Aiswarya, et al.
Publicado: (2017)

Biochemical and genetic analysis of RNA cap guanine-N2 methyltransferases from Giardia lamblia and Schizosaccharomyces pombe
por: Hausmann, Stéphane, et al.
Publicado: (2007)

Crystal structure of tRNA m(1)G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate
por: Shao, Zhenhua, et al.
Publicado: (2014)

Plasmid replication-associated single-strand-specific methyltransferases
por: Fomenkov, Alexey, et al.
Publicado: (2020)

Insights into the hyperthermostability and unusual region-specificity of archaeal Pyrococcus abyssi tRNA m(1)A57/58 methyltransferase
por: Guelorget, Amandine, et al.
Publicado: (2010)

Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria
por: Kaminska, Katarzyna H., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_f5bk3cit9niebhku1prg97kj1f