Cooperative cluster formation, DNA bending and base-flipping by O(6)-alkylguanine-DNA alkyltransferase

O(6)-Alkylguanine-DNA alkyltransferase (AGT) repairs mutagenic O(6)-alkylguanine and O(4)-alkylthymine adducts in DNA, protecting the genome and also contributing to the resistance of tumors to chemotherapeutic alkylating agents. AGT binds DNA cooperatively, and cooperative interactions are likely t...

Descripción completa

Detalles Bibliográficos
Autores principales: Tessmer, Ingrid, Melikishvili, Manana, Fried, Michael G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458534/
https://www.ncbi.nlm.nih.gov/pubmed/22730295
http://dx.doi.org/10.1093/nar/gks574

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458534/
https://www.ncbi.nlm.nih.gov/pubmed/22730295
http://dx.doi.org/10.1093/nar/gks574

Ejemplares similares