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Cooperative cluster formation, DNA bending and base-flipping by O(6)-alkylguanine-DNA alkyltransferase

O(6)-Alkylguanine-DNA alkyltransferase (AGT) repairs mutagenic O(6)-alkylguanine and O(4)-alkylthymine adducts in DNA, protecting the genome and also contributing to the resistance of tumors to chemotherapeutic alkylating agents. AGT binds DNA cooperatively, and cooperative interactions are likely t...

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Detalles Bibliográficos
Autores principales:	Tessmer, Ingrid, Melikishvili, Manana, Fried, Michael G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458534/ https://www.ncbi.nlm.nih.gov/pubmed/22730295 http://dx.doi.org/10.1093/nar/gks574

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