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Terminal deoxynucleotidyl transferase requires KU80 and XRCC4 to promote N-addition at non-V(D)J chromosomal breaks in non-lymphoid cells

Terminal deoxynucleotidyl transferase (TdT) is a DNA polymerase that increases the repertoire of antigen receptors by adding non-templated nucleotides (N-addition) to V(D)J recombination junctions. Despite extensive in vitro studies on TdT catalytic activity, the partners of TdT that enable N-additi...

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Detalles Bibliográficos
Autores principales:	Boubakour-Azzouz, Imenne, Bertrand, Pascale, Claes, Aurélie, Lopez, Bernard S., Rougeon, François
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458542/ https://www.ncbi.nlm.nih.gov/pubmed/22740656 http://dx.doi.org/10.1093/nar/gks585

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