Excision of thymine and 5-hydroxymethyluracil by the MBD4 DNA glycosylase domain: structural basis and implications for active DNA demethylation

The mammalian DNA glycosylase—methyl-CpG binding domain protein 4 (MBD4)—is involved in active DNA demethylation via the base excision repair pathway. MBD4 contains an N-terminal MBD and a C-terminal DNA glycosylase domain. MBD4 can excise the mismatched base paired with a guanine (G:X), where X is...

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Detalles Bibliográficos
Autores principales: Hashimoto, Hideharu, Zhang, Xing, Cheng, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458566/
https://www.ncbi.nlm.nih.gov/pubmed/22740654
http://dx.doi.org/10.1093/nar/gks628

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458566/
https://www.ncbi.nlm.nih.gov/pubmed/22740654
http://dx.doi.org/10.1093/nar/gks628

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