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CHK1 activity is required for continuous replication fork elongation but not stabilization of post-replicative gaps after UV irradiation

Ultraviolet (UV)-induced DNA damage causes an efficient block of elongating replication forks. The checkpoint kinase, CHK1 has been shown to stabilize replication forks following hydroxyurea treatment. Therefore, we wanted to test if the increased UV sensitivity caused by the unspecific kinase inhib...

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Detalles Bibliográficos
Autores principales:	Elvers, Ingegerd, Hagenkort, Anna, Johansson, Fredrik, Djureinovic, Tatjana, Lagerqvist, Anne, Schultz, Niklas, Stoimenov, Ivaylo, Erixon, Klaus, Helleday, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458576/ https://www.ncbi.nlm.nih.gov/pubmed/22753029 http://dx.doi.org/10.1093/nar/gks646

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