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Angiogenic squamous dysplasia-like phenomenon in oral epithelial precursor lesions

STATEMENT OF THE PROBLEM: Dysplasia, the morphological yardstick of epithelial precursor lesions, is the collective term for a variety of architectural and cytological changes within the altered oral epithelium. Angiogenic squamous dysplasia (ASD), a distinct morphological characteristic in pre-inva...

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Autores principales: Siar, CH, Oo, VPA, Nagatsuka, H, Nakano, K, Ng, KH, Kawakami, T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458642/
https://www.ncbi.nlm.nih.gov/pubmed/19661015
http://dx.doi.org/10.1186/2047-783X-14-7-315
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author Siar, CH
Oo, VPA
Nagatsuka, H
Nakano, K
Ng, KH
Kawakami, T
author_facet Siar, CH
Oo, VPA
Nagatsuka, H
Nakano, K
Ng, KH
Kawakami, T
author_sort Siar, CH
collection PubMed
description STATEMENT OF THE PROBLEM: Dysplasia, the morphological yardstick of epithelial precursor lesions, is the collective term for a variety of architectural and cytological changes within the altered oral epithelium. Angiogenic squamous dysplasia (ASD), a distinct morphological characteristic in pre-invasive bronchial lesions, describes the presence of capillary tufts that are closely juxtaposed to and projecting into the dysplastic bronchial epithelium. OBJECTIVE: To determine whether ASD-like phenomenon occurs in oral epithelial precursor lesions, and to speculate on its relevance. METHODS: Twenty cases each of mild, moderate and severe oral dysplasia (inclusive of carcinoma-in-situ), and 10 normal oral mucosa (normal controls) were serial sectioned for H and E staining, and for microvessel density (MVD) scoring with CD31, CD34 and CD105. Microcapillary pattern images were digitally captured for 3-D reconstruction. RESULTS: Oral ASD foci consisting of CD31-and CD34-positive capillary loops abutting onto the overlying dysplastic oral epithelium (and causing it to assume an irregular or papillary surface configuration) were identified in moderate (3/20; 15%) and severe dysplasia (13/20; 65%), but not in normal oral mucosa and mild dysplasia. MVD score demonstrated increasing vascularity as epithelium progressed from normal to severe dysplasia (p < 0.05). CD105 demonstrated increase neovascularization in all dysplasia grades (p < 0.05). CONCLUSIONS: These preliminary findings taken together suggest that: 1. ASD-like phenomenon may be an important intermediary biomarker in oral precursor lesions; and 2. architectural alterations of the entire disturbed mucosa may be a more useful pre-malignancy index.
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spelling pubmed-34586422012-09-27 Angiogenic squamous dysplasia-like phenomenon in oral epithelial precursor lesions Siar, CH Oo, VPA Nagatsuka, H Nakano, K Ng, KH Kawakami, T Eur J Med Res Research STATEMENT OF THE PROBLEM: Dysplasia, the morphological yardstick of epithelial precursor lesions, is the collective term for a variety of architectural and cytological changes within the altered oral epithelium. Angiogenic squamous dysplasia (ASD), a distinct morphological characteristic in pre-invasive bronchial lesions, describes the presence of capillary tufts that are closely juxtaposed to and projecting into the dysplastic bronchial epithelium. OBJECTIVE: To determine whether ASD-like phenomenon occurs in oral epithelial precursor lesions, and to speculate on its relevance. METHODS: Twenty cases each of mild, moderate and severe oral dysplasia (inclusive of carcinoma-in-situ), and 10 normal oral mucosa (normal controls) were serial sectioned for H and E staining, and for microvessel density (MVD) scoring with CD31, CD34 and CD105. Microcapillary pattern images were digitally captured for 3-D reconstruction. RESULTS: Oral ASD foci consisting of CD31-and CD34-positive capillary loops abutting onto the overlying dysplastic oral epithelium (and causing it to assume an irregular or papillary surface configuration) were identified in moderate (3/20; 15%) and severe dysplasia (13/20; 65%), but not in normal oral mucosa and mild dysplasia. MVD score demonstrated increasing vascularity as epithelium progressed from normal to severe dysplasia (p < 0.05). CD105 demonstrated increase neovascularization in all dysplasia grades (p < 0.05). CONCLUSIONS: These preliminary findings taken together suggest that: 1. ASD-like phenomenon may be an important intermediary biomarker in oral precursor lesions; and 2. architectural alterations of the entire disturbed mucosa may be a more useful pre-malignancy index. BioMed Central 2009-07-22 /pmc/articles/PMC3458642/ /pubmed/19661015 http://dx.doi.org/10.1186/2047-783X-14-7-315 Text en Copyright ©2009 I. Holzapfel Publishers
spellingShingle Research
Siar, CH
Oo, VPA
Nagatsuka, H
Nakano, K
Ng, KH
Kawakami, T
Angiogenic squamous dysplasia-like phenomenon in oral epithelial precursor lesions
title Angiogenic squamous dysplasia-like phenomenon in oral epithelial precursor lesions
title_full Angiogenic squamous dysplasia-like phenomenon in oral epithelial precursor lesions
title_fullStr Angiogenic squamous dysplasia-like phenomenon in oral epithelial precursor lesions
title_full_unstemmed Angiogenic squamous dysplasia-like phenomenon in oral epithelial precursor lesions
title_short Angiogenic squamous dysplasia-like phenomenon in oral epithelial precursor lesions
title_sort angiogenic squamous dysplasia-like phenomenon in oral epithelial precursor lesions
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458642/
https://www.ncbi.nlm.nih.gov/pubmed/19661015
http://dx.doi.org/10.1186/2047-783X-14-7-315
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