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Angiogenic squamous dysplasia-like phenomenon in oral epithelial precursor lesions
STATEMENT OF THE PROBLEM: Dysplasia, the morphological yardstick of epithelial precursor lesions, is the collective term for a variety of architectural and cytological changes within the altered oral epithelium. Angiogenic squamous dysplasia (ASD), a distinct morphological characteristic in pre-inva...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458642/ https://www.ncbi.nlm.nih.gov/pubmed/19661015 http://dx.doi.org/10.1186/2047-783X-14-7-315 |
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author | Siar, CH Oo, VPA Nagatsuka, H Nakano, K Ng, KH Kawakami, T |
author_facet | Siar, CH Oo, VPA Nagatsuka, H Nakano, K Ng, KH Kawakami, T |
author_sort | Siar, CH |
collection | PubMed |
description | STATEMENT OF THE PROBLEM: Dysplasia, the morphological yardstick of epithelial precursor lesions, is the collective term for a variety of architectural and cytological changes within the altered oral epithelium. Angiogenic squamous dysplasia (ASD), a distinct morphological characteristic in pre-invasive bronchial lesions, describes the presence of capillary tufts that are closely juxtaposed to and projecting into the dysplastic bronchial epithelium. OBJECTIVE: To determine whether ASD-like phenomenon occurs in oral epithelial precursor lesions, and to speculate on its relevance. METHODS: Twenty cases each of mild, moderate and severe oral dysplasia (inclusive of carcinoma-in-situ), and 10 normal oral mucosa (normal controls) were serial sectioned for H and E staining, and for microvessel density (MVD) scoring with CD31, CD34 and CD105. Microcapillary pattern images were digitally captured for 3-D reconstruction. RESULTS: Oral ASD foci consisting of CD31-and CD34-positive capillary loops abutting onto the overlying dysplastic oral epithelium (and causing it to assume an irregular or papillary surface configuration) were identified in moderate (3/20; 15%) and severe dysplasia (13/20; 65%), but not in normal oral mucosa and mild dysplasia. MVD score demonstrated increasing vascularity as epithelium progressed from normal to severe dysplasia (p < 0.05). CD105 demonstrated increase neovascularization in all dysplasia grades (p < 0.05). CONCLUSIONS: These preliminary findings taken together suggest that: 1. ASD-like phenomenon may be an important intermediary biomarker in oral precursor lesions; and 2. architectural alterations of the entire disturbed mucosa may be a more useful pre-malignancy index. |
format | Online Article Text |
id | pubmed-3458642 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-34586422012-09-27 Angiogenic squamous dysplasia-like phenomenon in oral epithelial precursor lesions Siar, CH Oo, VPA Nagatsuka, H Nakano, K Ng, KH Kawakami, T Eur J Med Res Research STATEMENT OF THE PROBLEM: Dysplasia, the morphological yardstick of epithelial precursor lesions, is the collective term for a variety of architectural and cytological changes within the altered oral epithelium. Angiogenic squamous dysplasia (ASD), a distinct morphological characteristic in pre-invasive bronchial lesions, describes the presence of capillary tufts that are closely juxtaposed to and projecting into the dysplastic bronchial epithelium. OBJECTIVE: To determine whether ASD-like phenomenon occurs in oral epithelial precursor lesions, and to speculate on its relevance. METHODS: Twenty cases each of mild, moderate and severe oral dysplasia (inclusive of carcinoma-in-situ), and 10 normal oral mucosa (normal controls) were serial sectioned for H and E staining, and for microvessel density (MVD) scoring with CD31, CD34 and CD105. Microcapillary pattern images were digitally captured for 3-D reconstruction. RESULTS: Oral ASD foci consisting of CD31-and CD34-positive capillary loops abutting onto the overlying dysplastic oral epithelium (and causing it to assume an irregular or papillary surface configuration) were identified in moderate (3/20; 15%) and severe dysplasia (13/20; 65%), but not in normal oral mucosa and mild dysplasia. MVD score demonstrated increasing vascularity as epithelium progressed from normal to severe dysplasia (p < 0.05). CD105 demonstrated increase neovascularization in all dysplasia grades (p < 0.05). CONCLUSIONS: These preliminary findings taken together suggest that: 1. ASD-like phenomenon may be an important intermediary biomarker in oral precursor lesions; and 2. architectural alterations of the entire disturbed mucosa may be a more useful pre-malignancy index. BioMed Central 2009-07-22 /pmc/articles/PMC3458642/ /pubmed/19661015 http://dx.doi.org/10.1186/2047-783X-14-7-315 Text en Copyright ©2009 I. Holzapfel Publishers |
spellingShingle | Research Siar, CH Oo, VPA Nagatsuka, H Nakano, K Ng, KH Kawakami, T Angiogenic squamous dysplasia-like phenomenon in oral epithelial precursor lesions |
title | Angiogenic squamous dysplasia-like phenomenon in oral epithelial precursor lesions |
title_full | Angiogenic squamous dysplasia-like phenomenon in oral epithelial precursor lesions |
title_fullStr | Angiogenic squamous dysplasia-like phenomenon in oral epithelial precursor lesions |
title_full_unstemmed | Angiogenic squamous dysplasia-like phenomenon in oral epithelial precursor lesions |
title_short | Angiogenic squamous dysplasia-like phenomenon in oral epithelial precursor lesions |
title_sort | angiogenic squamous dysplasia-like phenomenon in oral epithelial precursor lesions |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458642/ https://www.ncbi.nlm.nih.gov/pubmed/19661015 http://dx.doi.org/10.1186/2047-783X-14-7-315 |
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