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Asymmetric organocatalytic decarboxylative Mannich reaction using β-keto acids: A new protocol for the synthesis of chiral β-amino ketones
The first decarboxylative Mannich reaction employing β-keto acids, catalyzed by cinchonine-derived bifunctional thiourea catalyst has been described. The desired β-amino ketones were obtained in excellent yields and with moderate to good enantioselectivities.
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Beilstein-Institut
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458749/ https://www.ncbi.nlm.nih.gov/pubmed/23019459 http://dx.doi.org/10.3762/bjoc.8.144 |
| _version_ | 1782244694105784320 |
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| author | Jiang, Chunhui Zhong, Fangrui Lu, Yixin |
| author_facet | Jiang, Chunhui Zhong, Fangrui Lu, Yixin |
| author_sort | Jiang, Chunhui |
| collection | PubMed |
| description | The first decarboxylative Mannich reaction employing β-keto acids, catalyzed by cinchonine-derived bifunctional thiourea catalyst has been described. The desired β-amino ketones were obtained in excellent yields and with moderate to good enantioselectivities. |
| format | Online Article Text |
| id | pubmed-3458749 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2012 |
| publisher | Beilstein-Institut |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-34587492012-09-27 Asymmetric organocatalytic decarboxylative Mannich reaction using β-keto acids: A new protocol for the synthesis of chiral β-amino ketones Jiang, Chunhui Zhong, Fangrui Lu, Yixin Beilstein J Org Chem Letter The first decarboxylative Mannich reaction employing β-keto acids, catalyzed by cinchonine-derived bifunctional thiourea catalyst has been described. The desired β-amino ketones were obtained in excellent yields and with moderate to good enantioselectivities. Beilstein-Institut 2012-08-13 /pmc/articles/PMC3458749/ /pubmed/23019459 http://dx.doi.org/10.3762/bjoc.8.144 Text en Copyright © 2012, Jiang et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms) |
| spellingShingle | Letter Jiang, Chunhui Zhong, Fangrui Lu, Yixin Asymmetric organocatalytic decarboxylative Mannich reaction using β-keto acids: A new protocol for the synthesis of chiral β-amino ketones |
| title | Asymmetric organocatalytic decarboxylative Mannich reaction using β-keto acids: A new protocol for the synthesis of chiral β-amino ketones |
| title_full | Asymmetric organocatalytic decarboxylative Mannich reaction using β-keto acids: A new protocol for the synthesis of chiral β-amino ketones |
| title_fullStr | Asymmetric organocatalytic decarboxylative Mannich reaction using β-keto acids: A new protocol for the synthesis of chiral β-amino ketones |
| title_full_unstemmed | Asymmetric organocatalytic decarboxylative Mannich reaction using β-keto acids: A new protocol for the synthesis of chiral β-amino ketones |
| title_short | Asymmetric organocatalytic decarboxylative Mannich reaction using β-keto acids: A new protocol for the synthesis of chiral β-amino ketones |
| title_sort | asymmetric organocatalytic decarboxylative mannich reaction using β-keto acids: a new protocol for the synthesis of chiral β-amino ketones |
| topic | Letter |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458749/ https://www.ncbi.nlm.nih.gov/pubmed/23019459 http://dx.doi.org/10.3762/bjoc.8.144 |
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