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Synthesis and evaluation of new guanidine-thiourea organocatalyst for the nitro-Michael reaction: Theoretical studies on mechanism and enantioselectivity

A new guanidine-thiourea organocatalyst has been developed and applied as bifunctional organocatalyst in the Michael addition reaction of diethyl malonate to trans-β-nitrostyrene. Extensive DFT calculations, including solvent effects and dispersion corrections, as well as ab initio calculations prov...

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Detalles Bibliográficos
Autores principales:	Shubina, Tatyana E, Freund, Matthias, Schenker, Sebastian, Clark, Timothy, Tsogoeva, Svetlana B
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2012
Materias:	Full Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458773/ https://www.ncbi.nlm.nih.gov/pubmed/23019483 http://dx.doi.org/10.3762/bjoc.8.168

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