Expanding the chemical diversity of spirooxindoles via alkylative pyridine dearomatization

A mild and practical synthesis of spirooxindole [1,3]oxazino derivatives from N-substituted isatins and 1,3-dicarbonyl compounds with pyridine derivatives is reported. The reactions provided good to excellent yields. Further exploration of the molecular diversity of these compounds is demonstrated t...

Descripción completa

Detalles Bibliográficos
Autores principales: Dai, Chunhui, Liang, Bo, Stephenson, Corey R J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2012
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458780/
https://www.ncbi.nlm.nih.gov/pubmed/23019426
http://dx.doi.org/10.3762/bjoc.8.111
_version_ 1782244701384998912
author Dai, Chunhui
Liang, Bo
Stephenson, Corey R J
author_facet Dai, Chunhui
Liang, Bo
Stephenson, Corey R J
author_sort Dai, Chunhui
collection PubMed
description A mild and practical synthesis of spirooxindole [1,3]oxazino derivatives from N-substituted isatins and 1,3-dicarbonyl compounds with pyridine derivatives is reported. The reactions provided good to excellent yields. Further exploration of the molecular diversity of these compounds is demonstrated through Diels–Alder reactions.
format Online
Article
Text
id pubmed-3458780
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Beilstein-Institut
record_format MEDLINE/PubMed
spelling pubmed-34587802012-09-27 Expanding the chemical diversity of spirooxindoles via alkylative pyridine dearomatization Dai, Chunhui Liang, Bo Stephenson, Corey R J Beilstein J Org Chem Letter A mild and practical synthesis of spirooxindole [1,3]oxazino derivatives from N-substituted isatins and 1,3-dicarbonyl compounds with pyridine derivatives is reported. The reactions provided good to excellent yields. Further exploration of the molecular diversity of these compounds is demonstrated through Diels–Alder reactions. Beilstein-Institut 2012-07-02 /pmc/articles/PMC3458780/ /pubmed/23019426 http://dx.doi.org/10.3762/bjoc.8.111 Text en Copyright © 2012, Dai et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Letter
Dai, Chunhui
Liang, Bo
Stephenson, Corey R J
Expanding the chemical diversity of spirooxindoles via alkylative pyridine dearomatization
title Expanding the chemical diversity of spirooxindoles via alkylative pyridine dearomatization
title_full Expanding the chemical diversity of spirooxindoles via alkylative pyridine dearomatization
title_fullStr Expanding the chemical diversity of spirooxindoles via alkylative pyridine dearomatization
title_full_unstemmed Expanding the chemical diversity of spirooxindoles via alkylative pyridine dearomatization
title_short Expanding the chemical diversity of spirooxindoles via alkylative pyridine dearomatization
title_sort expanding the chemical diversity of spirooxindoles via alkylative pyridine dearomatization
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458780/
https://www.ncbi.nlm.nih.gov/pubmed/23019426
http://dx.doi.org/10.3762/bjoc.8.111
work_keys_str_mv AT daichunhui expandingthechemicaldiversityofspirooxindolesviaalkylativepyridinedearomatization
AT liangbo expandingthechemicaldiversityofspirooxindolesviaalkylativepyridinedearomatization
AT stephensoncoreyrj expandingthechemicaldiversityofspirooxindolesviaalkylativepyridinedearomatization

Ejemplares similares