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Dimerization of DOCK2 Is Essential for DOCK2-Mediated Rac Activation and Lymphocyte Migration

The migratory properties of lymphocytes depend on DOCK2, an atypical Rac activator predominantly expressed in hematopoietic cells. Although DOCK2 does not contain the Dbl homology domain typically found in guanine nucleotide exchange factors (GEFs), DOCK2 mediates the GTP-GDP exchange reaction for R...

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Detalles Bibliográficos
Autores principales:	Terasawa, Masao, Uruno, Takehito, Mori, Sayako, Kukimoto-Niino, Mutsuko, Nishikimi, Akihiko, Sanematsu, Fumiyuki, Tanaka, Yoshihiko, Yokoyama, Shigeyuki, Fukui, Yoshinori
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458822/ https://www.ncbi.nlm.nih.gov/pubmed/23050005 http://dx.doi.org/10.1371/journal.pone.0046277

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