Hypoxia Induces EMT in Low and Highly Aggressive Pancreatic Tumor Cells but Only Cells with Cancer Stem Cell Characteristics Acquire Pronounced Migratory Potential

Tumor hypoxia induces epithelial-mesenchymal transition (EMT), which induces invasion and metastasis, and is linked to cancer stem cells (CSCs). Whether EMT generates CSCs de novo, enhances migration of existing CSCs or both is unclear. We examined patient tissue of pancreatic ductal adenocarcinoma...

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Detalles Bibliográficos
Autores principales: Salnikov, Alexei V., Liu, Li, Platen, Mitja, Gladkich, Jury, Salnikova, Olga, Ryschich, Eduard, Mattern, Jürgen, Moldenhauer, Gerhard, Werner, Jens, Schemmer, Peter, Büchler, Markus W., Herr, Ingrid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458836/
https://www.ncbi.nlm.nih.gov/pubmed/23050024
http://dx.doi.org/10.1371/journal.pone.0046391

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