Viral Cross-Class Serpin Inhibits Vascular Inflammation and T Lymphocyte Fratricide; A Study in Rodent Models In Vivo and Human Cell Lines In Vitro

Poxviruses express highly active inhibitors, including serine proteinase inhibitors (serpins), designed to target host immune defense pathways. Recent work has demonstrated clinical efficacy for a secreted, myxomaviral serpin, Serp-1, which targets the thrombotic and thrombolytic proteases, suggesti...

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Detalles Bibliográficos
Autores principales: Viswanathan, Kasinath, Bot, Ilze, Liu, Liying, Dai, Erbin, Turner, Peter C., Togonu-Bickersteth, Babajide, Richardson, Jakob, Davids, Jennifer A., Williams, Jennifer M., Bartee, Mee Y., Chen, Hao, van Berkel, Theo J. C., Biessen, Erik A. L., Moyer, Richard W., Lucas, Alexandra R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458838/
https://www.ncbi.nlm.nih.gov/pubmed/23049756
http://dx.doi.org/10.1371/journal.pone.0044694

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