Weighted multiple testing procedures for genomic studies

With the rapid development of biological technology, measurement of thousands of genes or SNPs can be carried out simultaneously. Improved procedures for multiple hypothesis testing when the number of tests is very large are critical for interpreting genomic data. In this paper, we review recent dev...

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Detalles Bibliográficos
Autores principales: Gui, Jiang, Tosteson, Tor D, Borsuk, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458887/
https://www.ncbi.nlm.nih.gov/pubmed/22676256
http://dx.doi.org/10.1186/1756-0381-5-4
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author Gui, Jiang
Tosteson, Tor D
Borsuk, Mark
author_facet Gui, Jiang
Tosteson, Tor D
Borsuk, Mark
author_sort Gui, Jiang
collection PubMed
description With the rapid development of biological technology, measurement of thousands of genes or SNPs can be carried out simultaneously. Improved procedures for multiple hypothesis testing when the number of tests is very large are critical for interpreting genomic data. In this paper, we review recent developments on three distinct but closely related methods involving p-value weighting to improve statistical power while also controlling for the false discovery rate or the family wise error rate.
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spelling pubmed-34588872012-09-28 Weighted multiple testing procedures for genomic studies Gui, Jiang Tosteson, Tor D Borsuk, Mark BioData Min Review With the rapid development of biological technology, measurement of thousands of genes or SNPs can be carried out simultaneously. Improved procedures for multiple hypothesis testing when the number of tests is very large are critical for interpreting genomic data. In this paper, we review recent developments on three distinct but closely related methods involving p-value weighting to improve statistical power while also controlling for the false discovery rate or the family wise error rate. BioMed Central 2012-06-07 /pmc/articles/PMC3458887/ /pubmed/22676256 http://dx.doi.org/10.1186/1756-0381-5-4 Text en Copyright ©2012 Gui et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Gui, Jiang
Tosteson, Tor D
Borsuk, Mark
Weighted multiple testing procedures for genomic studies
title Weighted multiple testing procedures for genomic studies
title_full Weighted multiple testing procedures for genomic studies
title_fullStr Weighted multiple testing procedures for genomic studies
title_full_unstemmed Weighted multiple testing procedures for genomic studies
title_short Weighted multiple testing procedures for genomic studies
title_sort weighted multiple testing procedures for genomic studies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458887/
https://www.ncbi.nlm.nih.gov/pubmed/22676256
http://dx.doi.org/10.1186/1756-0381-5-4
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