Cargando…

PTEN/Akt Signaling Controls Mitochondrial Respiratory Capacity through 4E-BP1

Akt, a serine/threonine kinase has been shown to stimulate glycolysis in cancer cells but its role in mitochondrial respiration is unknown. Using PTEN-knockout mouse embryonic fibroblasts (MEF(PTEN−/−)) with hyper-activated Akt as a cell model, we observed a higher respiratory capacity in MEF(PTEN−/...

Descripción completa

Detalles Bibliográficos
Autores principales:	Goo, Chong Kiat, Lim, Hwee Ying, Ho, Qin Shi, Too, Heng-Phon, Clement, Marie-Veronique, Wong, Kim Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458951/ https://www.ncbi.nlm.nih.gov/pubmed/23049865 http://dx.doi.org/10.1371/journal.pone.0045806

Ejemplares similares

Mitochondrial Localized STAT3 Is Involved in NGF Induced Neurite Outgrowth
por: Zhou, Lihan, et al.
Publicado: (2011)

Normalization with genes encoding ribosomal proteins but not GAPDH provides an accurate quantification of gene expressions in neuronal differentiation of PC12 cells
por: Zhou, Lihan, et al.
Publicado: (2010)

Multienzyme Biosynthesis of Dihydroartemisinic Acid
por: Chen, Xixian, et al.
Publicado: (2017)

Enhancing solubility of deoxyxylulose phosphate pathway enzymes for microbial isoprenoid production
por: Zhou, Kang, et al.
Publicado: (2012)

Direct Quantification of mRNA and miRNA from Cell Lysates Using Reverse Transcription Real Time PCR: A Multidimensional Analysis of the Performance of Reagents and Workflows
por: Ho, Yoon Khei, et al.
Publicado: (2013)

Metabolite Profiling Identified Methylerythritol Cyclodiphosphate Efflux as a Limiting Step in Microbial Isoprenoid Production
por: Zhou, Kang, et al.
Publicado: (2012)

Combinatorial Engineering of 1-Deoxy-D-Xylulose 5-Phosphate Pathway Using Cross-Lapping In Vitro Assembly (CLIVA) Method
por: Zou, Ruiyang, et al.
Publicado: (2013)

Combining Genotype Improvement and Statistical Media Optimization for Isoprenoid Production in E. coli
por: Zhang, Congqiang, et al.
Publicado: (2013)

c-Jun N-terminal kinase in synergistic neurite outgrowth in PC12 cells mediated through P90RSK
por: Seow, Kok Huei, et al.
Publicado: (2013)

Multidimensional heuristic process for high-yield production of astaxanthin and fragrance molecules in Escherichia coli
por: Zhang, Congqiang, et al.
Publicado: (2018)

Novel reference genes for quantifying transcriptional responses of Escherichia coli to protein overexpression by quantitative PCR
por: Zhou, Kang, et al.
Publicado: (2011)

Trehalose significantly enhances the recovery of serum and serum exosomal miRNA from a paper-based matrix
por: Neo, Shu Hui, et al.
Publicado: (2017)

Enhanced non-viral gene delivery by coordinated endosomal release and inhibition of β-tubulin deactylase
por: Ho, Yoon Khei, et al.
Publicado: (2017)

PTEN inhibitor bpV(HOpic) confers protection against ionizing radiation
por: Chauhan, Ankit, et al.
Publicado: (2021)

Statistical Experimental Design Guided Optimization of a One-Pot Biphasic Multienzyme Total Synthesis of Amorpha-4,11-diene
por: Chen, Xixian, et al.
Publicado: (2013)

PTEN suppresses tumorigenesis by directly dephosphorylating Akt
por: Bu, Lang, et al.
Publicado: (2021)

circPTEN suppresses colorectal cancer progression through regulating PTEN/AKT pathway
por: Li, Chen, et al.
Publicado: (2021)

Exceptional Response to AKT Inhibition in Patients With Breast Cancer and Germline PTEN Mutations
por: Kingston, Belinda, et al.
Publicado: (2019)

Highly regio- and enantioselective multiple oxy- and amino-functionalizations of alkenes by modular cascade biocatalysis
por: Wu, Shuke, et al.
Publicado: (2016)

Cryopreservation does not change the performance and characteristics of allogenic mesenchymal stem cells highly over-expressing a cytoplasmic therapeutic transgene for cancer treatment
por: Ho, Yoon Khei, et al.
Publicado: (2022)

SYNJ2BP promotes the degradation of PTEN through the lysosome-pathway and enhances breast tumor metastasis via PI3K/AKT/SNAI1 signaling
por: Wang, Miao, et al.
Publicado: (2017)

Dysregulation of PI3K/Akt/PTEN Pathway in Canine Mammary Tumor
por: Kim, Soo-Hyeon, et al.
Publicado: (2021)

A highly efficient non-viral process for programming mesenchymal stem cells for gene directed enzyme prodrug cancer therapy
por: Ho, Yoon Khei, et al.
Publicado: (2020)

Impact of Adrenomedullin on Mitochondrial Respiratory Capacity in Human Adipocyte
por: Dong, Yuanlin, et al.
Publicado: (2023)

Impact of adrenomedullin on mitochondrial respiratory capacity in human adipocyte
por: Dong, Yuanlin, et al.
Publicado: (2023)

Inhibition of the AKT/mTOR pathway negatively regulates PTEN expression via miRNAs: Effect of Akt/mTOR inhibition on PTEN expression
por: Wan, Linyan, et al.
Publicado: (2022)

Fluctuations in AKT and PTEN Activity Are Linked by the E3 Ubiquitin Ligase cCBL
por: Olazábal-Morán, Manuel, et al.
Publicado: (2021)

Mitochondrial Dysfunction in Pten Haplo-Insufficient Mice with Social Deficits and Repetitive Behavior: Interplay between Pten and p53
por: Napoli, Eleonora, et al.
Publicado: (2012)

The effect Akt2 deletion on tumor development in Pten(+/−) mice
por: Xu, P-Z, et al.
Publicado: (2012)

Correlation of Sperm Mitochondrial DNA 7345 bp and 7599 bp Deletions with Asthenozoospermia in Jordanian Population
por: Zoubi, Mazhar Salim Al, et al.
Publicado: (2021)

RalA and RalBP1 regulate mitochondrial fission at mitosis
por: Kashatus, David F., et al.
Publicado: (2011)

Enhanced transfection of a macromolecular lignin-based DNA complex with low cellular toxicity
por: Ho, Yoon Khei, et al.
Publicado: (2018)

Development and validation of a circulating microRNA panel for the early detection of breast cancer
por: Zou, Ruiyang, et al.
Publicado: (2022)

Physical Fitness and Mitochondrial Respiratory Capacity in Horse Skeletal Muscle
por: Votion, Dominique-Marie, et al.
Publicado: (2012)

Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging?
por: Desler, Claus, et al.
Publicado: (2012)

PTEN regulation of the proliferation and differentiation of auditory progenitors through the PTEN/PI3K/Akt-signaling pathway in mice
por: Sun, Chen, et al.
Publicado: (2014)

Activation of PAR2 by tissue factor induces the release of the PTEN from MAGI proteins and regulates PTEN and Akt activities
por: Mohammad, Mohammad A., et al.
Publicado: (2020)

LY6E: a conductor of malignant tumor growth through modulation of the PTEN/PI3K/Akt/HIF-1 axis
por: Yeom, Chan Joo, et al.
Publicado: (2016)

lncNALT knockdown ameliorates hypertensive retinopathy via PTEN/PI3K/AKT pathway
por: Kang, Haijun, et al.
Publicado: (2023)

Preclinical Remodeling of Human Prostate Cancer through the PTEN/AKT Pathway
por: De Velasco, Marco A., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_d0sidcofj7l62l63pqve0id1b8