Cargando…
EPR Studies of DOPA–Melanin Complexes with Netilmicin and Cu(II) at Temperatures in the Range of 105–300 K
The application of electron paramagnetic resonance (EPR) spectroscopy in pharmacy of melanin complexes with netilmicin and Cu(II) was presented. The continuous microwave saturation of EPR spectra of DOPA–melanin and the complexes was performed. EPR spectra were measured on an X-band (9.3 GHz) spectr...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Vienna
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459086/ https://www.ncbi.nlm.nih.gov/pubmed/23144536 http://dx.doi.org/10.1007/s00723-012-0340-y |
_version_ | 1782244760383127552 |
---|---|
author | Zdybel, Magdalena Pilawa, Barbara Buszman, Ewa Wrześniok, Dorota Krzyminiewski, Ryszard Kruczyński, Zdzisław |
author_facet | Zdybel, Magdalena Pilawa, Barbara Buszman, Ewa Wrześniok, Dorota Krzyminiewski, Ryszard Kruczyński, Zdzisław |
author_sort | Zdybel, Magdalena |
collection | PubMed |
description | The application of electron paramagnetic resonance (EPR) spectroscopy in pharmacy of melanin complexes with netilmicin and Cu(II) was presented. The continuous microwave saturation of EPR spectra of DOPA–melanin and the complexes was performed. EPR spectra were measured on an X-band (9.3 GHz) spectrometer at temperatures in the range of 105–300 K. Paramagnetic copper ions decrease the intensity of the EPR lines of melanin’s free radicals. It was found that fast spin–lattice relaxation characterizes DOPA–melanin–Cu(II) complexes. Slow spin–lattice relaxation processes exist in melanin’s paramagnetic centers of DOPA–melanin and DOPA–melanin–netilmicin, [DOPA–melanin–netilmicin]–Cu(II), [DOPA–melanin–Cu(II)]–netilmicin complexes. Spin–lattice relaxation processes are faster at higher temperatures. The homogeneous broadening of EPR lines for melanin complexes was observed. The practical consequences of differences between paramagnetic properties of melanin complexes with netilmicin and the complexes with Cu(II) were discussed. |
format | Online Article Text |
id | pubmed-3459086 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Springer Vienna |
record_format | MEDLINE/PubMed |
spelling | pubmed-34590862012-11-09 EPR Studies of DOPA–Melanin Complexes with Netilmicin and Cu(II) at Temperatures in the Range of 105–300 K Zdybel, Magdalena Pilawa, Barbara Buszman, Ewa Wrześniok, Dorota Krzyminiewski, Ryszard Kruczyński, Zdzisław Appl Magn Reson Article The application of electron paramagnetic resonance (EPR) spectroscopy in pharmacy of melanin complexes with netilmicin and Cu(II) was presented. The continuous microwave saturation of EPR spectra of DOPA–melanin and the complexes was performed. EPR spectra were measured on an X-band (9.3 GHz) spectrometer at temperatures in the range of 105–300 K. Paramagnetic copper ions decrease the intensity of the EPR lines of melanin’s free radicals. It was found that fast spin–lattice relaxation characterizes DOPA–melanin–Cu(II) complexes. Slow spin–lattice relaxation processes exist in melanin’s paramagnetic centers of DOPA–melanin and DOPA–melanin–netilmicin, [DOPA–melanin–netilmicin]–Cu(II), [DOPA–melanin–Cu(II)]–netilmicin complexes. Spin–lattice relaxation processes are faster at higher temperatures. The homogeneous broadening of EPR lines for melanin complexes was observed. The practical consequences of differences between paramagnetic properties of melanin complexes with netilmicin and the complexes with Cu(II) were discussed. Springer Vienna 2012-05-13 2012 /pmc/articles/PMC3459086/ /pubmed/23144536 http://dx.doi.org/10.1007/s00723-012-0340-y Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Article Zdybel, Magdalena Pilawa, Barbara Buszman, Ewa Wrześniok, Dorota Krzyminiewski, Ryszard Kruczyński, Zdzisław EPR Studies of DOPA–Melanin Complexes with Netilmicin and Cu(II) at Temperatures in the Range of 105–300 K |
title | EPR Studies of DOPA–Melanin Complexes with Netilmicin and Cu(II) at Temperatures in the Range of 105–300 K |
title_full | EPR Studies of DOPA–Melanin Complexes with Netilmicin and Cu(II) at Temperatures in the Range of 105–300 K |
title_fullStr | EPR Studies of DOPA–Melanin Complexes with Netilmicin and Cu(II) at Temperatures in the Range of 105–300 K |
title_full_unstemmed | EPR Studies of DOPA–Melanin Complexes with Netilmicin and Cu(II) at Temperatures in the Range of 105–300 K |
title_short | EPR Studies of DOPA–Melanin Complexes with Netilmicin and Cu(II) at Temperatures in the Range of 105–300 K |
title_sort | epr studies of dopa–melanin complexes with netilmicin and cu(ii) at temperatures in the range of 105–300 k |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459086/ https://www.ncbi.nlm.nih.gov/pubmed/23144536 http://dx.doi.org/10.1007/s00723-012-0340-y |
work_keys_str_mv | AT zdybelmagdalena eprstudiesofdopamelanincomplexeswithnetilmicinandcuiiattemperaturesintherangeof105300k AT pilawabarbara eprstudiesofdopamelanincomplexeswithnetilmicinandcuiiattemperaturesintherangeof105300k AT buszmanewa eprstudiesofdopamelanincomplexeswithnetilmicinandcuiiattemperaturesintherangeof105300k AT wrzesniokdorota eprstudiesofdopamelanincomplexeswithnetilmicinandcuiiattemperaturesintherangeof105300k AT krzyminiewskiryszard eprstudiesofdopamelanincomplexeswithnetilmicinandcuiiattemperaturesintherangeof105300k AT kruczynskizdzisław eprstudiesofdopamelanincomplexeswithnetilmicinandcuiiattemperaturesintherangeof105300k |