Cargando…

EPR Studies of DOPA–Melanin Complexes with Netilmicin and Cu(II) at Temperatures in the Range of 105–300 K

The application of electron paramagnetic resonance (EPR) spectroscopy in pharmacy of melanin complexes with netilmicin and Cu(II) was presented. The continuous microwave saturation of EPR spectra of DOPA–melanin and the complexes was performed. EPR spectra were measured on an X-band (9.3 GHz) spectr...

Descripción completa

Detalles Bibliográficos
Autores principales: Zdybel, Magdalena, Pilawa, Barbara, Buszman, Ewa, Wrześniok, Dorota, Krzyminiewski, Ryszard, Kruczyński, Zdzisław
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459086/
https://www.ncbi.nlm.nih.gov/pubmed/23144536
http://dx.doi.org/10.1007/s00723-012-0340-y
_version_ 1782244760383127552
author Zdybel, Magdalena
Pilawa, Barbara
Buszman, Ewa
Wrześniok, Dorota
Krzyminiewski, Ryszard
Kruczyński, Zdzisław
author_facet Zdybel, Magdalena
Pilawa, Barbara
Buszman, Ewa
Wrześniok, Dorota
Krzyminiewski, Ryszard
Kruczyński, Zdzisław
author_sort Zdybel, Magdalena
collection PubMed
description The application of electron paramagnetic resonance (EPR) spectroscopy in pharmacy of melanin complexes with netilmicin and Cu(II) was presented. The continuous microwave saturation of EPR spectra of DOPA–melanin and the complexes was performed. EPR spectra were measured on an X-band (9.3 GHz) spectrometer at temperatures in the range of 105–300 K. Paramagnetic copper ions decrease the intensity of the EPR lines of melanin’s free radicals. It was found that fast spin–lattice relaxation characterizes DOPA–melanin–Cu(II) complexes. Slow spin–lattice relaxation processes exist in melanin’s paramagnetic centers of DOPA–melanin and DOPA–melanin–netilmicin, [DOPA–melanin–netilmicin]–Cu(II), [DOPA–melanin–Cu(II)]–netilmicin complexes. Spin–lattice relaxation processes are faster at higher temperatures. The homogeneous broadening of EPR lines for melanin complexes was observed. The practical consequences of differences between paramagnetic properties of melanin complexes with netilmicin and the complexes with Cu(II) were discussed.
format Online
Article
Text
id pubmed-3459086
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Springer Vienna
record_format MEDLINE/PubMed
spelling pubmed-34590862012-11-09 EPR Studies of DOPA–Melanin Complexes with Netilmicin and Cu(II) at Temperatures in the Range of 105–300 K Zdybel, Magdalena Pilawa, Barbara Buszman, Ewa Wrześniok, Dorota Krzyminiewski, Ryszard Kruczyński, Zdzisław Appl Magn Reson Article The application of electron paramagnetic resonance (EPR) spectroscopy in pharmacy of melanin complexes with netilmicin and Cu(II) was presented. The continuous microwave saturation of EPR spectra of DOPA–melanin and the complexes was performed. EPR spectra were measured on an X-band (9.3 GHz) spectrometer at temperatures in the range of 105–300 K. Paramagnetic copper ions decrease the intensity of the EPR lines of melanin’s free radicals. It was found that fast spin–lattice relaxation characterizes DOPA–melanin–Cu(II) complexes. Slow spin–lattice relaxation processes exist in melanin’s paramagnetic centers of DOPA–melanin and DOPA–melanin–netilmicin, [DOPA–melanin–netilmicin]–Cu(II), [DOPA–melanin–Cu(II)]–netilmicin complexes. Spin–lattice relaxation processes are faster at higher temperatures. The homogeneous broadening of EPR lines for melanin complexes was observed. The practical consequences of differences between paramagnetic properties of melanin complexes with netilmicin and the complexes with Cu(II) were discussed. Springer Vienna 2012-05-13 2012 /pmc/articles/PMC3459086/ /pubmed/23144536 http://dx.doi.org/10.1007/s00723-012-0340-y Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Article
Zdybel, Magdalena
Pilawa, Barbara
Buszman, Ewa
Wrześniok, Dorota
Krzyminiewski, Ryszard
Kruczyński, Zdzisław
EPR Studies of DOPA–Melanin Complexes with Netilmicin and Cu(II) at Temperatures in the Range of 105–300 K
title EPR Studies of DOPA–Melanin Complexes with Netilmicin and Cu(II) at Temperatures in the Range of 105–300 K
title_full EPR Studies of DOPA–Melanin Complexes with Netilmicin and Cu(II) at Temperatures in the Range of 105–300 K
title_fullStr EPR Studies of DOPA–Melanin Complexes with Netilmicin and Cu(II) at Temperatures in the Range of 105–300 K
title_full_unstemmed EPR Studies of DOPA–Melanin Complexes with Netilmicin and Cu(II) at Temperatures in the Range of 105–300 K
title_short EPR Studies of DOPA–Melanin Complexes with Netilmicin and Cu(II) at Temperatures in the Range of 105–300 K
title_sort epr studies of dopa–melanin complexes with netilmicin and cu(ii) at temperatures in the range of 105–300 k
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459086/
https://www.ncbi.nlm.nih.gov/pubmed/23144536
http://dx.doi.org/10.1007/s00723-012-0340-y
work_keys_str_mv AT zdybelmagdalena eprstudiesofdopamelanincomplexeswithnetilmicinandcuiiattemperaturesintherangeof105300k
AT pilawabarbara eprstudiesofdopamelanincomplexeswithnetilmicinandcuiiattemperaturesintherangeof105300k
AT buszmanewa eprstudiesofdopamelanincomplexeswithnetilmicinandcuiiattemperaturesintherangeof105300k
AT wrzesniokdorota eprstudiesofdopamelanincomplexeswithnetilmicinandcuiiattemperaturesintherangeof105300k
AT krzyminiewskiryszard eprstudiesofdopamelanincomplexeswithnetilmicinandcuiiattemperaturesintherangeof105300k
AT kruczynskizdzisław eprstudiesofdopamelanincomplexeswithnetilmicinandcuiiattemperaturesintherangeof105300k