Cargando…
Development of BOLD signal hemodynamic responses in the human brain
In the rodent brain the hemodynamic response to a brief external stimulus changes significantly during development. Analogous changes in human infants would complicate the determination and use of the hemodynamic response function (HRF) for functional magnetic resonance imaging (fMRI) in developing...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Academic Press
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459097/ https://www.ncbi.nlm.nih.gov/pubmed/22776460 http://dx.doi.org/10.1016/j.neuroimage.2012.06.054 |
_version_ | 1782244762753957888 |
---|---|
author | Arichi, Tomoki Fagiolo, Gianlorenzo Varela, Marta Melendez-Calderon, Alejandro Allievi, Alessandro Merchant, Nazakat Tusor, Nora Counsell, Serena J. Burdet, Etienne Beckmann, Christian F. Edwards, A. David |
author_facet | Arichi, Tomoki Fagiolo, Gianlorenzo Varela, Marta Melendez-Calderon, Alejandro Allievi, Alessandro Merchant, Nazakat Tusor, Nora Counsell, Serena J. Burdet, Etienne Beckmann, Christian F. Edwards, A. David |
author_sort | Arichi, Tomoki |
collection | PubMed |
description | In the rodent brain the hemodynamic response to a brief external stimulus changes significantly during development. Analogous changes in human infants would complicate the determination and use of the hemodynamic response function (HRF) for functional magnetic resonance imaging (fMRI) in developing populations. We aimed to characterize HRF in human infants before and after the normal time of birth using rapid sampling of the Blood Oxygen Level Dependent (BOLD) signal. A somatosensory stimulus and an event related experimental design were used to collect data from 10 healthy adults, 15 sedated infants at term corrected post menstrual age (PMA) (median 41 + 1 weeks), and 10 preterm infants (median PMA 34 + 4 weeks). A positive amplitude HRF waveform was identified across all subject groups, with a systematic maturational trend in terms of decreasing time-to-peak and increasing positive peak amplitude associated with increasing age. Application of the age-appropriate HRF models to fMRI data significantly improved the precision of the fMRI analysis. These findings support the notion of a structured development in the brain's response to stimuli across the last trimester of gestation and beyond. |
format | Online Article Text |
id | pubmed-3459097 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Academic Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-34590972012-11-01 Development of BOLD signal hemodynamic responses in the human brain Arichi, Tomoki Fagiolo, Gianlorenzo Varela, Marta Melendez-Calderon, Alejandro Allievi, Alessandro Merchant, Nazakat Tusor, Nora Counsell, Serena J. Burdet, Etienne Beckmann, Christian F. Edwards, A. David Neuroimage Article In the rodent brain the hemodynamic response to a brief external stimulus changes significantly during development. Analogous changes in human infants would complicate the determination and use of the hemodynamic response function (HRF) for functional magnetic resonance imaging (fMRI) in developing populations. We aimed to characterize HRF in human infants before and after the normal time of birth using rapid sampling of the Blood Oxygen Level Dependent (BOLD) signal. A somatosensory stimulus and an event related experimental design were used to collect data from 10 healthy adults, 15 sedated infants at term corrected post menstrual age (PMA) (median 41 + 1 weeks), and 10 preterm infants (median PMA 34 + 4 weeks). A positive amplitude HRF waveform was identified across all subject groups, with a systematic maturational trend in terms of decreasing time-to-peak and increasing positive peak amplitude associated with increasing age. Application of the age-appropriate HRF models to fMRI data significantly improved the precision of the fMRI analysis. These findings support the notion of a structured development in the brain's response to stimuli across the last trimester of gestation and beyond. Academic Press 2012-11-01 /pmc/articles/PMC3459097/ /pubmed/22776460 http://dx.doi.org/10.1016/j.neuroimage.2012.06.054 Text en © 2012 Elsevier Inc. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license |
spellingShingle | Article Arichi, Tomoki Fagiolo, Gianlorenzo Varela, Marta Melendez-Calderon, Alejandro Allievi, Alessandro Merchant, Nazakat Tusor, Nora Counsell, Serena J. Burdet, Etienne Beckmann, Christian F. Edwards, A. David Development of BOLD signal hemodynamic responses in the human brain |
title | Development of BOLD signal hemodynamic responses in the human brain |
title_full | Development of BOLD signal hemodynamic responses in the human brain |
title_fullStr | Development of BOLD signal hemodynamic responses in the human brain |
title_full_unstemmed | Development of BOLD signal hemodynamic responses in the human brain |
title_short | Development of BOLD signal hemodynamic responses in the human brain |
title_sort | development of bold signal hemodynamic responses in the human brain |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459097/ https://www.ncbi.nlm.nih.gov/pubmed/22776460 http://dx.doi.org/10.1016/j.neuroimage.2012.06.054 |
work_keys_str_mv | AT arichitomoki developmentofboldsignalhemodynamicresponsesinthehumanbrain AT fagiologianlorenzo developmentofboldsignalhemodynamicresponsesinthehumanbrain AT varelamarta developmentofboldsignalhemodynamicresponsesinthehumanbrain AT melendezcalderonalejandro developmentofboldsignalhemodynamicresponsesinthehumanbrain AT allievialessandro developmentofboldsignalhemodynamicresponsesinthehumanbrain AT merchantnazakat developmentofboldsignalhemodynamicresponsesinthehumanbrain AT tusornora developmentofboldsignalhemodynamicresponsesinthehumanbrain AT counsellserenaj developmentofboldsignalhemodynamicresponsesinthehumanbrain AT burdetetienne developmentofboldsignalhemodynamicresponsesinthehumanbrain AT beckmannchristianf developmentofboldsignalhemodynamicresponsesinthehumanbrain AT edwardsadavid developmentofboldsignalhemodynamicresponsesinthehumanbrain |