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Flagging and docking: dual roles for N-glycans in protein quality control and cellular proteostasis
Nascent polypeptides entering the endoplasmic reticulum (ER) are covalently modified with pre-assembled oligosaccharides. The terminal glucose and mannose residues are immediately removed after transfer of the oligosaccharide onto newly synthesized polypeptides. This processing determines whether th...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier Ltd.
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459134/ https://www.ncbi.nlm.nih.gov/pubmed/22921611 http://dx.doi.org/10.1016/j.tibs.2012.07.005 |