Prevalence of 185delAG and 5382insC mutations in BRCA1, and 6174delT in BRCA2 in women of Ashkenazi Jewish origin in southern Brazil

Certain mutations in BRCA1 and BRCA2 genes are frequent in the Ashkenazi Jewish population. Several factors contribute to this increased frequency, including consanguineous marriages and an event known as a “bottleneck”, which occurred in the past and caused a drastic reduction in the genetic variab...

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Detalles Bibliográficos
Autores principales: Dillenburg, Crisle Vignol, Bandeira, Isabel Cristina, Tubino, Taiana Valente, Rossato, Luciana Grazziotin, Dias, Eleonora Souza, Bittelbrunn, Ana Cristina, Leistner-Segal, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2012
Materias:
Human and Medical Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459409/
https://www.ncbi.nlm.nih.gov/pubmed/23055798
http://dx.doi.org/10.1590/S1415-47572012000400009

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